Suzuki反应合成联苯酚类化合物  

Synthesis of Biphenol Derivatives via Suzuki Coupling Reaction

作　　者：姜祎 徐虹[1] 莫玲超[2] 杨咪[1] JIANG Yi XU Hong. MO Ling-chao YANG Mi(Col- lege of Pharmacy, Shanxi University of Chinese Medicine, Xianyang 712046, China Xi＇an Modern Chemistry Research Institu- te,Xi＇an 710065 ,China)

机构地区：[1]陕西中医药大学药学院,陕西咸阳712046 [2]西安近代化学研究所,陕西西安710065

出　　处：《化学试剂》2017年第2期211-214,共4页Chemical Reagents

摘　　要：以取代苯硼酸、溴代苯酚为原料,四(三苯基膦)合钯为催化剂,在过量K_2CO_3、KOH为混合碱的条件下,经Suzuki反应合成联苯酚类化合物。产物结构经~1HNMR、^(13)CNMR、IR和MS确证,该体系可通过提高Suzuki反应的氧化加成步骤促进反应快速高效地进行,产率达95%。该反应体系可用于联苯酚类化合物的合成。To investigate new synthesis of biphenol derivatives via Suzuki coupling reaction in an alkaline environment. The aryl boric acid and phenol bromide were used as raw material,KOH and K_2CO_3 mixture as mixed alkali and Pd（PPh_3）_4as catalyst.The Suzuki reaction could be improved by increasing the addition of oxidation step with high yield of 95% and the structures of product were confirmed by-1HNMR,-（13）CNMR,IR and MS. This synthesis could be used to synthesize biphenol derivatives.

关 键 词：SUZUKI反应 联苯酚 混合碱 

分 类 号：TQ031.2[化学工程]