循环微小RNA诊断心肌病变的研究进展  

Research progress of circulating miRNA in the diagnosis of myocardial lesions

作　　者：张楚婕[1,2,3] 程蕾蕾[1,2,3] ZHANG Chu-jie CHENG Lei-lei(Department of Echoeardiography , Zhongshan Hospital, Fudan University, Shanghai 200032, China Shanghai Institute of Cardiovascular Disease, Shanghai 200032, China Shanghai Institute of Medical Imaging, Shanghai 200032, China)

机构地区：[1]复旦大学附属中山医院心脏超声诊断科,上海200032 [2]上海市心血管病研究所,上海200032 [3]上海市影像医学研究所,上海200032

出　　处：《复旦学报（医学版）》2017年第1期110-116,共7页Fudan University Journal of Medical Sciences

基　　金：国家自然科学基金(81201095);复旦大学附属中山医院优秀骨干计划(2015ZSYXGG04)~~

摘　　要：微小RNA(microRNA,miRNA)是一组长度为19~25个核苷酸的非编码RNA,在细胞增殖、分化、发育及死亡过程中发挥重要作用。在血浆中稳定存在并可检测的miRNA称为循环miRNA。近年来研究表明循环miRNA可作为诊断心肌病变的新型潜在生物标志物。本文就循环miRNA早期诊断心力衰竭、心肌梗死及药物性心脏毒性等心肌病变的临床与实验研究进展作一综述。MicroRNA（ miRNA） is a class of 19-25-nucleotide non-coding RNAs that plays an important role in cellular proliferation,differentiation,development as well as cell death. The miRNA that can be detected in the plasma is known as circulating miRNA,and it can exist stable in the circulation of the blood.Recently,circulating miRNA has been increasingly suggested as novel potential biomarkers of a series of myocardial lesions. This review article summarized the progress of clinical and experimental studies of circulating miRNA as early diagnosis index for cardiopathologic conditions,including acute myocardial infarction,heart failure along with drug-induced cardiotoxicity.

关 键 词：循环miRNA 生物标志物 急性心肌梗死 心力衰竭 肥厚型心肌病 心房颤动 药物性心脏毒性 

分 类 号：R542.22[医药卫生—心血管疾病]