Intra-individual comparison of different gadolinium-based contrast agents in the quantitative evaluation of C6 glioma with dynamic contrast-enhanced magnetic resonance imaging  

作　　者：Ying Li Gang Liu Xin Lou Zhiye Chen Lin Ma 

机构地区：[1]Department of Radiology, PLA General Hospital, Beijing 100853, China

出　　处：《Science China(Life Sciences)》2017年第1期11-15,共5页中国科学（生命科学英文版）

摘　　要：This experiment aimed to compare the ionic （Gadodiamide, Gd-DTPA-BMA） and non-ionic （Gadopentetate dimeglumine, Gd-DTPA） gadolinium-based contrast agents （GBCA） in the quantitative evaluation of C6 glioma with dynamic contrast-enhanced magnetic resonance imaging （DCE-MRI）. A C6 glioma model was established in 12 Wistar rats, and magnetic resonance （MR） scans were performed six days after tumor implantation. Imaging was performed using a 3.0-T MR scanner with a 7-inch handmade circular coil. Pre-contrast T1 mapping and dynamic contrast-enhanced T1WI after a bolus injection （0.2 mL s 1） of GBCA at 0.4 mmol kg-1 were performed. Each rat received two DCE-MRI scans, 24 h apart. The first and second scans were performed using Gd-DTPA-BMA and Gd-DTPA, respectively. Image data were processed using the Patlak model. Both Kns and Vp maps were generated. Tumors were manually segmented on all 3D K and Vp maps. Pixel counts and mean values were recorded for use in a paired t-test. Three radiologists independently performed the tumor segmentation and value calculation. The agreements from different observers were subjective to the intra-class correlation coefficient （ICC）. Readers demonstrated that the pixel counts of tumors in/Crns maps were higher with Gd-DTPA-BMA than with Gd-DTPA （P〈0.001, all readers）. Although the/（r,,s values were higher with Gd-DTPA-BMA than with Gd-DTPA, there was no statistical significance （P〉0.05, all readers）. The pixel counts of tumors in Vp maps, as well as Vp values, showed no obvious difference between the two agents （P〉0.05, all readers）. Excellent interobserver measurement reproducibility and reliability were demonstrated in the ICC tests. The Gd-DTPA-BMA contrast agent had significantly higher pixel counts of glioma in the maps, and an increased tendency for average/Us values, indicating that DCE-MRI with Gd-DTPA-BMA may be more suitable and sensitive for the evaluation of glioma.This experiment aimed to compare the ionic(Gadodiamide,Gd-DTPA-BMA) and non-ionic(Gadopentetate dimeglumine,Gd-DTPA) gadolinium-based contrast agents(GBCA) in the quantitative evaluation of C6 glioma with dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI).A C6 glioma model was established in 12 Wistar rats,and magnetic resonance(MR)scans were performed six days after tumor implantation.Imaging was performed using a 3.0-T MR scanner with a 7-inch handmade circular coil.Pre-contrast T1 mapping and dynamic contrast-enhanced T1 WI after a bolus injection(0.2 mL s^(-1)) of GBCA at 0.4 mmol kg^(-1) were performed.Each rat received two DCE-MRI scans,24 h apart.The first and second scans were performed using Gd-DTPA-BMA and Gd-DTPA,respectively.Image data were processed using the Patlak model.Both K^(trans)and V_p maps were generated.Tumors were manually segmented on all 3D K^(trans) and V_p maps.Pixel counts and mean values were recorded for use in a paired f-test Three radiologists independently performed the tumor segmentation and value calculation.The agreements from different observers were subjective to the intra-class correlation coefficient(ICC).Readers demonstrated that the pixel counts of tumors in K^(trans) maps were higher with Gd-DTPA-BMA than with Gd-DTPA(P<0.001,all readers).Although the K^(trans) values were higher with Gd-DTPA-BMA than with Gd-DTPA,there was no statistical significance(P>0.05,all readers).The pixel counts of tumors in V_p maps,as well as V_p values,showed no obvious difference between the two agents(P>0.05,all readers).Excellent interobserver measurement reproducibility and reliability were demonstrated in the ICC tests.The Gd-DTPA-BMA contrast agent had significantly higher pixel counts of glioma in the K^(trans) maps,and an increased tendency for average K^(trans) values,indicating that DCE-MRI with Gd-DTPA-BMA may be more suitable and sensitive for the evaluation of glioma.

关 键 词：dynamic contrast enhanced MR Ktrans Gd-DTPA-BMA GD-DTPA IONIC NON-IONIC 

分 类 号：R445.2[医药卫生—影像医学与核医学] R739.41[医药卫生—诊断学]