氟哌啶醇药物相互作用的研究进展  

Research Progress in Drug Interactions of Haloperidol

作　　者：雷凯[1] 黄渊[1] 张思[1] 贺国芳[1] 刘东[1] 任秀华[1] Lei Kai Huang Yuan Zhang Si He Guofang Liu Dong Ren Xiuhua(Department of Pharmacy of Ton~i Hospital, Ton~i Medi- cal School, Huazhong Science and Technology University, Wuhan 430030, China)

机构地区：[1]华中科技大学同济医学院附属同济医院药学部,武汉430030

出　　处：《中国药师》2017年第2期334-337,共4页China Pharmacist

基　　金：湖北省自然科学基金面上项目(编号:2016CFB628)

摘　　要：目的:总结氟哌啶醇与其他药物的药物相互作用,为氟哌啶醇的临床安全、合理、有效使用提供参考。方法:通过检索Micromedex~、Pubmed、中国期刊全文数据库(CNKI)等检索源,总结分析氟哌啶醇与其他药物之间的相互作用情况。结果:氟哌啶醇作用于多巴胺受体并主要经肝脏细胞色素P450(CYP)酶系代谢,其他药物与氟哌啶醇合用时,药物可通过影响CYP酶或多巴胺受体等方式可能产生潜在临床意义的药动学和药效学相互作用。结论:临床上应该合理、谨慎地选择与氟哌啶醇联用的药物,做到安全、有效、合理用药。Objective ： To summarize the drug interactions of haloperidol used in combination with the other drugs to provide refer- ence for safe, reasonable and effective use of haloperido] in clinics. Methods： By retrieving Micromedex, Pubmed, CNKI and so on, the interactions between haloperidol and the other drugs were summarized and analyzed. Results： The effect of haloperidol was on do- pamine receptors, and haloperidol was mainly metabolized by hepatic cytochrome P450 （CYP） enzymes. When haloperidol was com- bined with the other drugs, significant interactions of pharmacokinetics and pharmacodynamics were induced by affecting CYP enzymes or dopamine receptor. Conclusion： In clinical practice, the other drugs combined with haloperidol should be reasonable and careful to ensure safe, effective and rational drug use.

关 键 词：氟哌啶醇 药物相互作用 CYP2D6 CYP3A4 多巴胺受体 

分 类 号：R969.2[医药卫生—药理学]