他汀类药物诱发糖尿病的机制综述  

Mechanisms of Diabetogenic Action of Statins

作　　者：刘书源[1] 苏伊新[1] Liu Shuyuan Su Yixin(Department of Pharmacy, Ordos Central Hospital, Inner Mongolia Ordos 017000, China)

机构地区：[1]鄂尔多斯市中心医院药剂科,内蒙古鄂尔多斯017000

出　　处：《中国药师》2017年第2期337-339,共3页China Pharmacist

摘　　要：目的:警示他汀类药物对血糖的影响,为临床合理使用他汀类调脂药提供依据。方法:查阅国外近年报道的他汀类药物对血糖影响的因素及机制相关文献,并进行归纳总结。结果与结论:他汀类调脂药,尤其是脂溶性他汀药物能通过多种机制引起血糖升高,诱发糖尿病。可能的机制包括阻断钙离子通道、增加细胞内血源性低密度脂蛋白-胆固醇的量、抑制ATP和辅酶Q10的生成、抑制葡萄糖转运体4的基因表达、诱导胰岛β细胞炎性反应氧化及凋亡等。在临床上使用他汀类药物时,应注意监测血糖,及时调整用药。Objective： To alarm the effect of statins on blood glucose, and provide evidence for the rational use of statins in clin- ics. Methods ： The recent articles on the effects and potential mechanisms of diabetogenic action of statins were reviewed and summa- rized. Results and Conclusion： Stains, especially lipophilic stains, could increase blood glucose via multiple pathways to induce dia- betes. The potential mechanisms included inhibiting L-type calcium channel, increasing the uptake of plasma-derived LDL-C, inhibi- ting synthesis of ATP and Coenzyme Q10, inhibiting the expression of glucose transporter 4 and inducing β-cell inflammation, oxidation and apoptosis. Blood glucose should be monitored and adjusted timely when statins are used in clinics.

关 键 词：他汀类药物 胰岛素抵抗 糖尿病 机制 

分 类 号：R972.6[医药卫生—药品]