氟康唑滴眼液抑菌剂浓度筛选和抑菌效力研究  

Concentration Screening and Antimicrobial Effectiveness of Antimicrobial Preservative for Fluconazole Eye Drop

作　　者：刘峰 孟蕾蕾 王国平 朱萍 Liu Feng Meng Leilei Wang Guoping Zhu Ping(Food and Drug Inspection and Testing Center of Rizhao City, Shandong Rizhao 276800, Chin)

机构地区：[1]日照市食品药品检验检测中心,山东日照276800

出　　处：《中国药师》2017年第2期362-364,共3页China Pharmacist

摘　　要：目的:探讨氟康唑滴眼液中抑菌剂的合理添加剂量。方法:按照中国药典2015年版抑菌剂效力检查法,以金黄色葡萄球菌、铜绿假单胞菌、大肠埃希菌、白色念珠菌和黑曲霉为试验菌株,对分别含4个不同浓度抑菌剂(5%,1%,0.3%,0.1%苯扎氯铵)的氟康唑滴眼液进行抑菌剂效力测定。结果:含5%,1%,0.3%苯扎氯铵的氟康唑滴眼液对金黄色葡萄球菌、铜绿假单胞菌、大肠埃希菌、白色念珠菌和黑曲霉5种试验菌的抑菌效力均符合规定,0.1%苯扎氯铵对铜绿假单胞菌抑菌效力不符合规定,0.3%为苯扎氯铵的最低抑菌浓度。结论:确定苯扎氯铵的最佳抑菌浓度为1%。Objective： To explore the reasonable amount of bacteriostatis agent in fluconazole eye drop. Methods： According to the method of bacteriostatis effect test in 2015 edition of Chinese Pharmacopoeia （ ChP）, and Staphyococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Candia albicans and Aspergillus niger as the test strains, the bacteriostatis effect of fluconazole eye drop containing 5%, 1% , 0.3% and 0.1% benzalkonium chloride was determined. Results： The bacteriostatis effects of fluconazole eye drop containing 5% , 1% and 0.3% benzalkonium chloride on the five species of tested bacteria complied with the regulations of ChP. The bacteriostatis effects of 0.1% benzalkonium chloride on Pseudomonas aeruginosa didn＇t meet the requirements, therefore, 0.3% was the minimum inhibitory concentration （MIC） of benzalkonium chloride. Conclusion ： The best inhibitory concentration of benza- lkonium chloride is 1%.

关 键 词：氟康唑滴眼液 抑菌剂 抑菌效力 苯扎氯铵 

分 类 号：R94[医药卫生—药剂学]