抗抑郁中药新药研发进展  

Progress of new antidepressant drugs development

作　　者：张潇[1,2] 田俊生[1] 刘欢[3] 秦雪梅[1] 

机构地区：[1]山西大学中医药现代研究中心,山西太原030006 [2]山西大学化学化工学院,山西太原030006 [3]中国辐射防护研究院药物安全评价中心,山西太原030006

出　　处：《中国中药杂志》2017年第1期29-33,共5页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目(81441096;81173366;81473415);国家国际科技合作项目(2011DFA32630);山西省重点研发计划项目(201603D321077;201603D3113013)

摘　　要：抑郁症严重危害人类身心健康,世界卫生组织预测到2020年抑郁症将成为非正常死亡和残疾的第二大原因。目前抑郁症仍以药物为主治疗,但已上市抗抑郁药并不理想,因此开发疗效更高、特点明显、不良反应更少的新型抗抑郁药物是新药研发者追求的目标。该文归纳总结了目前已上市、处于新药研发及新药发现阶段的抗抑郁中药及天然药物,旨在为抗抑郁新药研发提供参考。Depression becomes more and more serious and has been greatly do harm to human＇s physical and mental health. WHO predicts that depression will become the second leading cause of abnormal death and disability by 2020. There is still the drug treatment as the first-line antidepressive therapy, but the effect of listed antidepressant drugs is not ideal Therefore, discovery of new antidepres- sant drug of sunique, higher curative effect, less adverse reaction is the pursuit of pharmaceutical. The traditional Chinese medicine （TCM） of anti-depression and natural antidepressant in currently listed, drug development and drug discovery phase are summarized in this paper, aiming to provide reference for new antidepressant drug research.

关 键 词：抗抑郁药 新药研发 抗抑郁中药 抗抑郁天然药物 

分 类 号：R283.6[医药卫生—中药学]