提高微生物合成萜类化合物产量的策略  

Strategies for Improving The Yield of Microbial Terpenoids Production

作　　者：张中素 杨瑞刚[1] 朱凌云[1] 吴小敏[1] ZHANG Zhong-su YANG Rui-gang ZHU Ling-yun WU Xiao-min(Department of Chemistry and Biology, College of Science, National University of Defense Technology, Changsha 410073, China)

机构地区：[1]国防科学技术大学理学院化学与生物学系,长沙410073

出　　处：《中国生物工程杂志》2017年第1期97-103,共7页China Biotechnology

基　　金：国防科技大学科研计划资助项目(ZK16-03-13;JC14-02-09;JC14-09-03)

摘　　要：萜类化合物种类繁多、结构复杂,在医药、能源等领域具有重要的应用价值。当前萜类化合物主要是从植物中提取或化学法合成,费效比较高,而微生物合成成本低、效率高,更具有发展潜力,但由于萜类代谢通路复杂、微生物自身代谢调控精细以致难以人为操控,多数萜类化合物尚未通过微生物合成获得可观的产量。对此,对提高微生物合成萜类化合物的策略进行综述,旨在为萜类化合物在微生物中的生产与研究提供参考。Terpenoids,a family of compounds with a wide range of diversity and structural complexity,play important roles in the fields of pharmaceutics and energy. The terpenoid compounds are mainly extracted from plants or chemically synthesized,which are both cost-effectiveness. On contrary,the economic and efficient way of microbial synthesis is more promising. However,due to the complexity of theterpenoidsynthesis pathway and the difficult manipulation of the host metabolic networks, most terpenoid compounds have notbiologically synthesized inan agreeable yield. Here,the strategies for improving the yield of microbial terpenoids production.

关 键 词：萜类化合物 微生物合成 代谢通路 提高产量 

分 类 号：Q946.8[生物学—植物学]