急性心肌梗死患者高敏C反应蛋白与梗死相关血管早期自发再通的相关性研究  

Association between hs-CRP and infarc-related arteries early spontaneous recanalization in acute STEMI patients

作　　者：师树田[1] 李艳芳[1] 艾辉[1] 阙斌[1] 王春梅[1] 聂绍平[1] SHI Shu-tian LI Yan-fang AI Hui et al(Emergency and Critical Care Center,Affiliated Beijing Anzhen Hospital of Capital Medical University, Beijing 100029, China)

机构地区：[1]首都医科大学附属北京安贞医院急诊危重症中心,100029

出　　处：《中华老年心脑血管病杂志》2017年第2期137-139,共3页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

基　　金：国家自然科学基金(81270284);北京市自然科学基金(7141003);北京市科技计划项目(Z141107002514014)

摘　　要：目的探讨急性ST段抬高型心肌梗死(ST-segment elevation myocardial infarction,STEMI)患者入院时高敏C反应蛋白(high-sensitivity C-reactive protein,hs-CRP)水平与梗死相关血管早期自发再通的直接相关性。方法收集2014年1月~2015年12月北京安贞医院诊断为急性STEMI患者268例,按照冠状动脉造影梗死相关血管TIMI血流分级分为血管未通组181例(TIMI 0~Ⅰ级),血管再通组87例(TIMIⅡ~Ⅲ级)。入院后立即采集外周静脉血,由中心化验室检测hs-CRP,常规行超声心动图检查,所有患者在症状发生12h内行冠状动脉造影。结果血管未通组与血管再通组梗死相关血管(左前降支、左回旋支和右冠状动脉)、病变血管(单支病变、双支病变和3支病变)比较,差异无统计学意义(P>0.05)。血管再通组hs-CRP水平明显低于血管未通组,差异有统计学意义[(18.69±21.23)mg/L vs(25.17±24.36)mg/L,P<0.05]。结论入院hs-CRP水平在急性STEMI患者早期血管再通中明显降低。Objective To study the direct association between high-sensitivity C-reactive protein（hs-CRP）and infarc-related early spontaneous recanalization in acute ST-segment elevation myocardial infarction（STEMI）patients.Methods Two hundred and sixty-eight acute STEMI patients admitted to our hospital from January 2014 to December 2015 were divided into non-recanalization group（n=181）and recanalization group（n=87）according to their TIMI score.Peripheral venous blood samples were taken immediately after admission for the measurement of their serum hs-CRP level.The patients underwent routine echocardiography and coronary angiography within 12 hafter the development of symptoms.Results No significant difference was found in infarc-related spontaneous recanalization of left ancerior descending branch,left circumflex branch,right coronary branch and in single vessel lesion,double vessel lesion and triple vessel lesion between the two groups（P〉0.05）.The serum hs-CRP level was significantly lower in recanalization group than in non-revascularization group（18.69±21.23mg/L vs 25.17±24.36mg/L,P〈0.05）.Conclusion The serum hs-CRP level is significantly lower in acute STEMI patients on admission than in early spontaneous recanalization.

关 键 词：心肌梗死 C反应蛋白质 冠状血管造影术 动脉粥样硬化 心肌缺血 

分 类 号：R542.22[医药卫生—心血管疾病]