白眉长臂猿感染戊型肝炎病毒的病理学观察  

Observation of the Pathology of Hepatitis E Virus Infection in Hoolock leuconedys

作　　者：安俊卿[1] 戴榕全 汤金[1] 卢岩[2] 佘锐萍[1] 田纪景[1] 石蕊寒[1] 常玲玲[1] 张成林[2] An dunqing Dai Rongquan Tang din Lu Yan She Ruiping Tian Jijing Shi Ruihan Chang Lingling Zhang Chenglin(College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China Beijing Zoo, Beijing, 100044, China)

机构地区：[1]中国农业大学动物医学院,北京100193 [2]北京动物园,北京100044

出　　处：《野生动物学报》2017年第1期115-121,共7页CHINESE JOURNAL OF WILDLIFE

摘　　要：2010年3月8日,北京动物园1只白眉长臂猿突发死亡,通过组织病理学和免疫组织化学等方法对该病死白眉长臂猿死因进行分析。大体剖检观察显示心脏表面可见灰白色病灶,肝脏表面散在大小不一黄白色病灶,肾脏成土黄色,肺脏大面积出血,胃黏膜有散在出血点,肠道水肿,肠系膜淋巴结肿大。病理组织学观察结果显示心肌坏死严重,肺脏严重出血并含有大量炎性细胞浸润,肝脏肝细胞变性坏死并有大量的炎性细胞浸润,肾脏肾小管上皮细胞变性坏死,肾小管管腔中含有黄绿色的小结晶体,肠黏膜水肿。免疫组织化学检测肝脏、肾脏戊型肝炎病毒ORF 2阳性。综合诊断该白眉长臂猿因感染戊型肝炎病毒而导致抵抗力减弱,从而导致肾脏肾小管蛋白凝集发生结晶,引发尿毒症,而后导致心肌坏死,从而导致死亡。On 8 March 2010,a Hoolock leuconedys died suddenly at Beijing Zoo.We conducted histopathology and immunohistochemistry to analyze the cause of death.Gross autopsy showed white lesions on the surface of the heart and different sizes of yellow-white lesions on the surface of the liver.The kidney became soil yellow and severe hemorrhage was found in the lung.There were scattered bleeding spots in the stomach mucous membrane.The intestine showed edema and the mesenteric lymph node was dilated.Per the results of histopathology,the myocardium showed severe necrosis.Many inflammatory cell infiltrations were discovered together with severe pulmonary hemorrhage in the lung.Examination of the liver revealed degeneration,necrosis and inflammatory cell infiltration.Large numbers of tubular epithelial cells were degenerative and obviousyellow green crystals were found in the renal tubes.The intestinal mucosal showed edema.Immunohistochemistry results revealed that HEV ORF 2 antigen was positive in the liver and kidney.Per these results,we established that infection of hepatitis E virus in the Hylobates hoolock caused weakened resistance resulting from protein agglutination in renal tubes which induced crystallization uremia.Finally,myocardial necrosis was severe and led to the death of the gibbon.

关 键 词：白眉长臂猿 戊型肝炎病毒 肝炎 肺炎 肾炎 

分 类 号：S859.8[农业科学—临床兽医学]