冠脉慢血流与血管内皮功能的关系研究  

Relationship between slow coronary flow and vascular endothelial function

作　　者：郝亚逢[1] 刘俊法[1] 李杨[1] 李远[2] 王献忠[1] 靳文军[1] HAO Ya-feng LIU Jun-fa LI Yang LI Yuan WANG Xian-zhong JIN Wen-jun(Second Department of Cardiology, First Hospital of Handan City, Handan, Hebei, 056002, Chin)

机构地区：[1]邯郸市第一医院心内二科,河北邯郸056002 [2]河北省石家庄市第四医院内科

出　　处：《心血管康复医学杂志》2017年第1期52-55,共4页Chinese Journal of Cardiovascular Rehabilitation Medicine

基　　金：邯郸市科学技术研究与发展计划项目(1423108063-6)~~

摘　　要：目的:研究分析冠状动脉慢血流与血管内皮功能的关系。方法:选择我院2014年1月到12月接受冠状动脉造影的患者共88例。采用TIMI血流分级法对所有患者的冠状动脉血流速度进行评价,凡校正TIMI帧数(CTFC)>27帧为慢血流,有慢血流者被分为冠脉慢血流组(43例),血流正常者被分为正常对照组(45例)。检测比较两组的血压、血糖、血脂水平及血管内皮功能。采用Logistic回归分析冠脉慢血流与血管内皮功能的关系。结果:两组的血压、血糖和血脂水平均无显著差异,P均>0.05。与正常对照组比较,冠脉慢血流组的肱动脉血流介导的血管舒张功能[FMD,(8.33±2.04)%比(7.06±1.78)%]和硝酸甘油依赖的血管扩张功能[NMD,(20.39±4.13)%比(16.10±5.22)%]均显著降低,P均<0.01。Logistic回归分析结果显示,降低的FMD(OR=1.069,P=0.011)和NMD(OR=1.183,P=0.014)是冠脉慢血流的危险因素。结论:血管内皮功能损害是冠脉慢血流的危险因素。Objective： To study and analyze the relationship between slow coronary flow （SCF） and vascular endothelial func- tion. Methods： A total of 88 patients, who received coronary angiography in our hospital from Jan 2014 to Dec 2014, were selected. TIMI blood flow classification was used to assess coronary flow velocity of all patients. The CTFC （corrected TIMI frame count） 〉27 frames was regarded as slow flow. The patients with slow flow were regarded as SCF group （n = 43）, and those with normal blood flow were regarded as normal control group （n=45）. Levels of blood pressure, blood glucose and blood lipids, and vascular endothelial function were measured and compared between two groups. Logistic regression analysis was used to analyze the relationship between SCF and vascular endothelial function. Results： There were no significant difference in levels of blood pressure, blood glucose and blood lipids between two groups, P〉0.05 all. Compared with normal control group, there were significant reductions in fore brachial artery flow-mediated vascular diastolic function [FMD, （8. 33 ± 2.04）% vs. （7. 06 ± 1.78）%] and nitroglycerin mediated vasodilation [NMD, （20.39 ± 4. 13）% vs. （16. 10± 5.22）%] in SCF group, P〈0. 01 both. Logistic regression analysis indicated that reduced FMD （OR = 1. 069, P = 0. 011） and NMD （OR = 1. 183, P = 0. 014） were risk factors for SCF. Conclusion.. The vascular endothelial dysfunction is a risk factor of slow coronary flow.

关 键 词：血流速度 内皮 血管 冠状血管 

分 类 号：R541.409[医药卫生—心血管疾病]