热熔挤出法联合静电纺丝法制备新型抗炎缓释系统  

Preparation of A Novel Degradable Anti-inflammatory Sustain Release System By Combination of Hot Melt Extrusion and Electrospining Method

作　　者：王连嵩[1,2] 殷莉莉[1] 刘冬[1] 郑玉强[1] 何伟[1] WANG Lian-song YIN Li-li LIU Dong ZHENG Yu-qiang HE Wei(Sehool of Pharmacy, He University, Shenyang 110163, China Eye Hospital, China Academy of Chinese Medical Sciences, Beijing 110040, China)

机构地区：[1]辽宁何氏医学院药学院,辽宁沈阳110163 [2]中国中医科学院眼科医院,北京110040

出　　处：《合成化学》2017年第2期140-143,共4页Chinese Journal of Synthetic Chemistry

基　　金：辽宁省科学技术计划项目"热熔挤出法制备新型眼内植入缓释系统关键技术开发"(2013226064)

摘　　要：报道了一种制备具有"核-壳"结构和双重释放过程的可降解抗炎缓释系统(3)的新方法。以聚(乙交酯-丙交酯)(PLGA50)为药物载体,先通过热熔挤出法将绿原酸(CA)与PLGA50共挤出得挤出物(1);利用静电纺丝法在1表面包裹一层"PLGA50+CA"静电纺丝膜(2),制得具备"核-壳"结构的材料(3)。采用SEM,TGA,DSC和LC-MS研究了CA的热稳定性,1的热力学性能,3的微观形态和体外药物释放行为。结果表明:3具有"核-壳"结构;引入CA,降低了PLGA50的玻璃化转变温度;3的药物释放为双重释放过程。A novel method of preparing degradable anti-inflammatory sustain release system with ＂core-shell＂ structure and double drug sustain release system（3） was reported. Extrude（ 1 ） was prepared by hot melt extrusion method, using PLGAS0 and chlorogenic acid （CA） as the co-extrude. 3 was obtained by warping a ＂PLGA50 ＋ CA＂ layer （2） on the surface of 1 via electrospining method. Thermostability of CA, thermoproperties of 1, microscopic morphology and in vitro drug release behavior of 3 were investigated by SEM, TGA, DSC and LC-MS. The results indicated that 3 obtains ＂coreshell＂ structure. The Tg of PLGA50 decreased for the introduction of CA. The in vitro drug release process of 3 was a double-release process.

关 键 词：聚(乙交酯-丙交酯) 绿原酸 热熔挤出法 静电纺丝法 核-壳结构 制备 双重释放 

分 类 号：O63[理学—高分子化学] R944.9[理学—化学]