聚乙二醇-b-聚赖氨酸/C_(60)/ZnTPPS胶束及功能化研究  

Functional Properties of PEG-b-PLys/C_(60)/ZnTPPS Micelle

作　　者：柴志华[1] 李昂[1] 安英丽[1] 史林启[1] Zhi-hua Chai Ang Li Ying-li An Lin-qi Shi(Key Laboratory of Functional Polymer Materials of Ministry of Education, State Key Laboratory of Medicinal Chemical Biology, Institute of Polymer Chemistry, Nankai University, Tianjin 300071)

机构地区：[1]南开大学高分子化学研究所药物化学生物学国家重点实验室功能高分子材料教育部重点实验室,天津300071

出　　处：《高分子学报》2017年第2期393-398,共6页Acta Polymerica Sinica

基　　金：国家自然科学基金项目(基金号51503064);天津市自然科学基金青年项目(基金号16JCQNJC03000)资助项目

摘　　要：利用嵌段共聚物胶束将C_(60)和5,10,15,20-四-(4-对磺酸基苯基)-锌卟啉(ZnTPPS)同时负载,在水相中实现电荷传递以扩大其应用范围.通过对Zn TPPS在复合胶束内的光学稳定性测定,发现C_(60)的存在使ZnTPPS的稳定性得到极大的提高.以甲基紫精(MV^(2+))为模型化合物,发现复合胶束光催化还原MV^(2+)能力最强,证明该复合胶束具有较强电子转移的能力和较高的光学活性.Block copolymer micelles of poly（ethylene glycol）-block-poly（L-lysine）（PEG-b-PLys） was used to load fullerene（C60） and zinc tetrakis（4-sulfonatophenyl） porphyrin（ZnTPPS） in water. The diblock copolymer of PEG-b-PLys was firstly synthesized via ring-opening polymerization. Then the PEG-b-PLys/C60 micelles were prepared by association between PEG-b-PLys and C60 in aqueous solution. ZnTPPS was added to the PEG-b-PLys/C60 micelle solution and PEG-b-PLys/C60/ZnTPPS complex micelles were finally obtained by electrostatic interaction between ZnTPPS and PLys. The structure and photochemical properties of the PEG-b-PLys/C60/ZnTPPS complex micelles were characterized by dynamic light scattering, transmission electron microscopy, UV-Visible spectroscopy and fluorescence spectroscopy. The results showed that the PEG-b-PLys/C60/ZnTPPS complex micelles were reasonably monodisperse with an average hydrodynamic diameter of 80 nm. The complex micelles showed the typical UV-Vis spectra of ZnTPPS and C60. The Soret-band peak of ZnTPPS in the complex micelles was red-shifted from 421 to 430 nm, which was possibly caused by electron transfer from the ZnTPPS to the fullerene. In addition, the fluorescence emission spectra of ZnTPPS was obviously quenched in the complex micelles. These results suggested that ZnTPPS was assembled successfully into PEG-b-PLys/C60 micelles. In order to investigate the role of C60 in the photoprotection of ZnTPPS, the illumination of ZnTPPS encapsulated in different micelles was carried out under identical conditions using a 360 nm cut-off filter. Compared with ZnTPPS in the PEG-b-PLys/ZnTPPS electrostatic micelles, the ZnTPPS loaded in the complex micelles possessed higher photostability because of the reduced generation of singlet oxygen. The photoreduction of methyl viologen hydrate（MV^2＋） was chosen as the model reaction to evaluate the electron-transfer efficiency of the complex micelles. The amount of MV^＋ produced by the complex micelles was higher than that by both f

关 键 词：富勒烯 锌卟啉 复合胶束 光学活性 

分 类 号：O641.4[理学—物理化学]