含1,3,4-噻二唑的吡啶联吡唑乙酰胺类化合物的合成及除草活性  

Synthesis and herbicidal activity of substituted 2-(1-(3-chloropyridin-2-yl)-3,5-dimethyl-1H-pyrazol-4-yl) acetic acid derivatives containing1, 3, 4-thiadiazole

作　　者：胡燕红[1] 何海琴[1] 刘幸海[1] 翁建全[1] 谭成侠[1] HU Yanhong HE Haiqing LIU Xinghai WENG Jianquan TAN Chengxia(College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China)

机构地区：[1]浙江工业大学化学工程学院,杭州310014

出　　处：《农药学学报》2017年第1期114-118,共5页Chinese Journal of Pesticide Science

摘　　要：以乙酰丙酮、溴乙酸乙酯和2,6-二氯吡啶为起始原料,经取代、肼基化、环合、水解、酸化及缩合等反应,得到9个未见文献报道的吡啶联吡唑乙酰基类化合物B1~B9。其结构均经核磁共振氢谱和质谱表征。初步生物活性测定表明:在150 g/hm^2的处理剂量下,大部分目标化合物表现出一定的除草活性,其中化合物B2、B3、B6和B8对苘麻Abutilon theophrasti Medicus、反枝苋Amaranthus retroflexus和凹头苋Amaranthus lividus L.生长的抑制率接近100%。Nine novel 2-（1-（3-chloro pyridin-2-yl）-3,5-dimethyl-1H-pyrazol-4-yl） acetic acid derivatives B1-B9 were synthesized from acetylacetone, ethyl bromoacetate and 2,6-dichloropyridine. The synthesis route included a series of reactions such as substitution, alkylation, cyclization, hydrolysis,and acidification condensation. The chemical structures were characterized by ^1H NMR and MS.Preliminary bioassay showed that most of the above compounds displayed herbicidal activities at the concentration of 150 g/hm^2. The inhibition rates of B2, B3, B6 and B8 against Abutilon theophrasti Medicus, Amaranthus retroflexus and Amaranthus lividus L. were nearly 100%.

关 键 词：1 3 4-噻二唑 吡啶联吡唑 乙酰胺类衍生物 合成 除草活性 

分 类 号：O626.2[理学—有机化学] S482.4[理学—化学]