C3肾小球病研究新进展  

New advancements of C3 glomerulopathy

作　　者：王畅[1] 陈超[1] 孙林[1] Wang Chang Chen Chao Sun Lin(Department of Nephrology, The Second Xiangya Hospital of Central South University/Institute of Kidney Dis- ease, Central South University, Changsha 410011, China)

机构地区：[1]中南大学湘雅二医院肾内科/中南大学肾脏病研究所,长沙410011

出　　处：《中国医师杂志》2017年第1期32-37,共6页Journal of Chinese Physician

摘　　要：C3肾小球病（C3G）是由于补体激活、降解及沉积紊乱而引起的补体c3在肾小球的沉积，导致肾小球损伤。研究发现循环和（或）肾小球基底膜内C3b的扩大是引起免疫紊乱的关键因素。本文结合临床及实验研究，主要探讨该病的发病机制、临床特征以及治疗。C3 glomerulopathy （C3G） is referred to disease which is out of control of complement activation, degradation and deposition, then leads to predominant C3 deposition in glomerular and glomeru- lar injury. The study found that C3b amplification in the circulation and/or glomerular basement membrane were the key factors that cause immune disorders. Combined with clinical and experimental research, this paper mainly discusses the pathogenesis, clinical characteristics, and treatment of the disease.

关 键 词：肾小球.肾炎 补体C3 补体C3b 

分 类 号：R692.6[医药卫生—泌尿科学]