三种中和剂对常用手消毒剂中和效果的实验观察  

Experimental observation on neutralizing effect of using three neutralizers to the common hand disinfectants

作　　者：曾其莉[1] 江永忠[1] 张静玲[1] 李国明[1] 宋毅[1] ZENG Qi-li JIANG Yong-zhong ZHANG Jing-ling LI Guo-ming SONG Yi(Hubei Provincial Center for Disease Prevention and Control,Wuhan Hubei 430079,Chin)

机构地区：[1]湖北省疾病预防控制中心,湖北武汉430079

出　　处：《中国消毒学杂志》2017年第1期28-30,共3页Chinese Journal of Disinfection

基　　金：湖北省预防医学会2015年消毒领域科研创新项目(XKC2015-02);中华预防医学会2013年消毒领域科研创新专项(2013ZY003)

摘　　要：目的观察3种中和剂对常用手消毒剂的中和效果,为科学评价手消毒剂的消毒效果提供参考。方法采用悬液定量杀菌试验方法和规范的6组设计方案,评价3种中和剂对常用手消毒剂涉及的聚六亚甲基双胍、氯己定、复合季铵盐和三氯羟基二苯醚等4种有效成分的中和效果。结果中和剂A对5种手消毒剂原液和稀释液均不能有效中和;中和剂B仅能中和稀释后的低浓度聚六亚甲基双胍、氯己定和复合季铵盐;中和剂C可中和中高浓度的聚六亚甲基双胍、氯己定和复合季铵盐。3种中和剂对含三氯羟基二苯醚的手消毒剂原液和稀释液均不能有效中和。结论中和剂C即D/E中和肉汤,对聚六亚甲基双胍、氯己定、复合季铵盐等多类手消毒剂的中和剂鉴定有实用意义,对于含三氯羟基二苯醚消毒剂的中和剂筛选仍然是难点,需要进一步实验和探索。Objective To observe the neutralizing effect of neutralizer for the common hand disinfectants,and to provide a reference for scientific evaluation of hand disinfectant. Methods Evaluating the effect of three neutralizers for the hand dis-infectants which containing polyhexamethylene biguanide、chlorhexidine、compound quaternary ammonium salt or triclosan with suspension quantitative germicidal test. Results Neutralizer A could not neutralize effectively the five hand disinfect-ants;Neutralizer B could neutralize effectively the four hand disinfectants with low concentration;Neutralizer C could neu-tralize effectively the four hand disinfectants with middle and high concentration;Triclosan could not be neutralized with three neutralizers. Conclusion C is D/E neutralizing broth medium which is useful to neutralizer verification test. But the neutralizer verification test for the neutralizer containing triclosan is still difficult,which still calls for further research and confirmation.

关 键 词：中和剂 手消毒剂 胍类 季铵盐 三氯羟基二苯醚 

分 类 号：R187.1[医药卫生—流行病学]