结核病患者血清细胞因子检测的临床意义  

Clinical Study of Serum Cytokines in Tuberculosis Patients

作　　者：席向宇 王炳花 XI Xiang-yu WANG Bing-hua(Xuzhou Infectious Disease Hospital, Xuzhou, Jiangsu, 221004, China)

机构地区：[1]徐州市传染病医院,江苏徐州221004 [2]徐州医科大学,江苏徐州221004

出　　处：《黑龙江医学》2017年第1期5-6,共2页Heilongjiang Medical Journal

基　　金：徐州市科技局社会发展基金(NO.KC14SH054)

摘　　要：目的了解结核病患者和正常对照血清中人白细胞介素12(IL-12)、人白细胞介素18(IL-18)、干扰素(IFN-γ)和肿瘤坏死因子-α(TNF-α)的水平,探讨这些细胞因子在结核病发病中的临床意义。方法采用酶联免疫方法(Enzyme-linked immuno sorbent assay,ELISA)检测60例肺结核患者和60例正常对照血清中IL-12、IL-18、IFN-γ和TNF-α的水平。结果结核组血清中IL-12、IL-18、IFN-γ和TNF-α的浓度均高于对照组,差异有统计学意义(P<0.05)。结论感染结核后可使患者血清中的细胞因子浓度升高。Objective To explore the level of IL-12,IL-18,IFN -α and TNF-α of serum and their clinical significance in tuberculosis patients. Methods The levels of IL-12, IL-18, IFN -γ and TNF-α of 60 tuberculosis patients and healthy people were examined through using ELISA method. Results The levels of IL-12, IL-18, IFN - γ and TNF-α in tuberculosis group were higher than control group（P 〈 0.05）. Conclusion The levels of serum cytokine will increase in tuberculosis patients.

关 键 词：结核分枝杆菌 细胞因子 酶联免疫法 

分 类 号：R521[医药卫生—内科学]