枸橼酸与肝素在连续性肾脏替代治疗抗凝中的安全性比较  

Comparison of Citrate Anticoagulation and Heparin Anticoagulation in Safety of CRRT

作　　者：肖仁威 钟小婷[1] 农凌波[2] XIAO Ren-wei ZHONG Xiao-ting NONG Ling-bo(Department of ICU, Yingde People＇s Hospital, Qingyuan, Guangdong, 513000, China)

机构地区：[1]英德市人民医院重症医学科,广东清远513000 [2]广州医科大学第一附属医院重症医学科,广东广州510100

出　　处：《黑龙江医学》2017年第1期7-8,共2页Heilongjiang Medical Journal

基　　金：徐州市科技局社会发展基金(NO.KC14SH054)

摘　　要：目的比较枸橼酸钠抗凝与肝素抗凝在连续性肾脏替代治疗(continuous renal replacement therapy,CRRT)中的安全性。方法将广州医科大学第一附属医院ICU从2015-09—2016-05间行CRRT治疗的64例患者随机分为肝素组(32例)和枸橼酸组(32例)。通过对比滤器使用寿命、非正常下机事件、出血事件等因素来评价两者安全性。结果在滤器使用寿命上,肝素组(18.1±6.8)h vs枸橼酸组(20.2±7.5)h,两组差异无统计学意义(P>0.05)。但在非正常下机事件发生上,肝素组明显高于枸橼酸组。出血事件上,肝素组远高于枸橼酸组,差异均有统计学意义(P<0.05)。结论 CRRT治疗中,枸橼酸钠抗凝比肝素抗凝更安全。Objective To compare citrate anticoagulation with heparin anticoagulation in safety of continuous renal replacement therapy （CRRT）. Methods 64 patients were collected from ICU Department of The First Affiliated Hospital of Guangzhou Medical University from September, 2015 to May, 2016. They were randomly divided into heparin group （32 cases） and citrate （32 cases）. By comparing the filter life time, unplaned stop, bleeding events and other factors of 2 groups were used to evaluate safety. Results There is no statistical difference （P〉 0.05） in the filter life time through comparing heparin group（18.1 ± 6.8）h with citrate group（20.2±7.5）h. While in unplaned stop, heparin group are much higher than citrate group. And heparin group is much higher than citrate group in bleeding events. There is statistical difference （P 〈 0.05）. Conclusion Citrate is safer than heparin in CRRT antieoagulation.

关 键 词：连续性肾脏替代治疗 枸橼酸 肝素 

分 类 号：R457[医药卫生—治疗学]