人类胎盘滋养层细胞的分化与妊娠相关疾病  

Human placental trophoblast differentiation and related diseases

作　　者：王红梅[1] 杜美蓉[2] WANG Hong-Mei DU Mei-Rong(The State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, B eijing 100101, China Laboratory for Reproductive Immunology, Hospital and Institute of Obstetrics and Gynecology, Fudan University Shanghai Medical College, Shanghai 200011, China)

机构地区：[1]中国科学院动物研究所干细胞与生殖生物学国家重点实验室,北京100101 [2]复旦大学附属妇产科医院,上海200011

出　　处：《生命科学》2017年第1期15-20,共6页Chinese Bulletin of Life Sciences

基　　金：国家杰出青年科学基金项目(81225004);科技部重大科学研究计划(2011CB944403;2006CB944008;2006CB504006;2015CB943300);国家自然科学基金重点项目(81630036);国家自然科学基金重大项目培养计划(91542116)

摘　　要：胎儿发育过程中,胎盘既作为胎儿寄生于母体的中介,又在一定程度上充当胎儿的肾脏、肝脏、胃肠道以及呼吸、内分泌和免疫等系统,对母体和胎儿孕期,甚至终生的健康至关重要。然而,胎盘却是了解的最少的人类器官。随着现代生物学技术的发展,人类对胎盘的认识正在从简单的组织结构层面上升到细胞、分子层面,并逐渐走向组学和系统生物学时代。人类对胎盘认识的深入必将为改善妊娠结局提供重要的理论基础和技术路径。The placenta functions as an autonomous organ that supports the development of the embryo, and also serves, to a certain extent, as the kidney, liver, intestinal tracts and respiratory, endocrine and immune systems of the fetus. However, our knowledge on the human placenta is very limited. With the development of modern biology, researches on placental biology have extended from pure histomorphology to cellular and molecular biology, and will finally enter into an era of omics and systemic biology. A comprehensive understanding of the human placentawill provide a theoretical basis for the clinical diagnosis and treatment of pregnancy-associated diseases and hence improve pregnancy outcome.

关 键 词：人类胎盘 滋养层细胞 妊娠相关疾病 

分 类 号：Q492.6[生物学—生理学] R714.56[医药卫生—妇产科学]