厦门、深圳及广州鼠形动物脑组织寨卡病毒携带情况检测  

Prevalence of Zika virus in brain tissues of rodent animals trapped in Xiamen,Shenzhen and Guangzhou cities

作　　者：霍舒婷 莫云[1] 熊益权[1] 李东亮[1] 邱旻[1] 郑雪燕[1] 陈少威[1] 钟雪珊[1] 葛婧[1] 蒋丽娜[1] 马淑娟[1] 程明基 陈清[1] 

机构地区：[1]南方医科大学公共卫生学院流行病学系,广东广州510515

出　　处：《中国公共卫生》2017年第2期233-235,共3页Chinese Journal of Public Health

基　　金：国家自然科学基金(81373051)

摘　　要：目的了解福建厦门、广东深圳及广州的鼠形动物脑组织标本寨卡病毒的携带情况,分析鼠形动物作为人类寨卡病毒病潜在传染源的可能性。方法于2013年1月—2016年6月在厦门、深圳及广州(白云区、越秀区)部分居民区、城市公园、医院、农贸市场、学校捕获鼠形动物,无菌采集其脑组织样本,用逆转录聚合酶链反应(RT-PCR)方法检测寨卡病毒核酸。结果本次调查共捕获鼠形动物1 092只2目2科3属7种,家鼠以褐家鼠为优势鼠种(59.84%),野鼠以黄毛鼠为优势鼠种(98.02%);共获1 092份脑组织标本,RT-PCR方法在采集的脑组织标本中均未检测出寨卡病毒核酸。结论厦门、深圳及广州鼠形动物作为寨卡病毒病传染源的可能性小。Objective To examine the prevalence of Zika virus in brain tissues from rodent animals trapped in Xiamen, Shenzhen and Guangzhou city, and to explore whether rodent animals are potential sources of human Zika virus infection. Methods Rodent animals were trapped in residential areas, urban parks, hospitals, markets, and schools in Xiamen, Shenzben and Guangzhou （Yuexiu and Baiyun districts） between January 2013 and June 2016. Brain tissues of the trapped animals were collected under sterile condition. Zika virus in the brain tissue samples was detected with reverse transcription polymerase chain reaction （RT-PCR）. Results Totally 1 092 rodent animals of 7 species,3 genera,2 families, and 2 orders were trapped. Rattus norvegicus was the dominant species （59. 84% ,593/991 ） trapped in indoor environment and Rattus losea was the dominant （98.02% ,99/101 ） in wild environment. No Zika virus nucleic acid positive samples were detected for all the samples. Conclusion The possibility is low for rodent animals being the source of Zika virus infection in Xiamen, Shenzhen and Guangzhou city.

关 键 词：寨卡病毒 鼠形动物 脑组织 

分 类 号：R511[医药卫生—内科学]