FIB和D-二聚体联合GRACE评分与急性冠脉综合征的风险预测  

FIB and D-D with GRACE Risk Score to Predict the Risk of Acute Coronary Syndrome

作　　者：杨阳[1,2] 吴嘉[1] 汪俊军[1] 

机构地区：[1]南京大学医学院附属金陵医院临床检验科,南京210002 [2]金坛区人民医院检验科,江苏常州213200

出　　处：《现代检验医学杂志》2017年第1期99-102,共4页Journal of Modern Laboratory Medicine

基　　金：国家自然科学基金(81271904;81401742;81572073;81572074);国家重大科学仪器设备开发专项(2012YQ03026109)

摘　　要：目的探讨纤维蛋白原(FIB)、D-二聚体(D-D)联合GRACE评分对急性冠脉综合征(ACS)患者风险预测。方法分别检测90例ACS患者,23例健康体检者血浆FIB,D-D,GRACE评分及ACS患者冠状动脉病变支数,分析其相关性。结果 ACS患病组FIB,D-D和GRACE评分分别为2.77±0.79 g/L,1.67±2.13 mg/L,147.19±32.50.分,与对照组(2.77±0.13 g/L,0.21±0.08 mg/L,92.30±19.5分)比较显著增高,差异有统计学意义(t=6.256,6.465,10.317,P值均<0.001);血浆D-D,FIB含量在不同的危险分层比较,差异有统计学意义(F=18.475,9.426,P值均<0.001);相关性分析显示ACS患者血浆D-D(r=0.485,P<0.000 1),FIB(r=0.357,P<0.000 6)含量与GRACE评分呈正相关关系。结论ACS患者血浆的FIB,D-D和GRACE评分均升高,FIB和D-D可作为ACS的风险预测因子,D-D的预测价值优于FIB。Objective To investigate FIB and D-D with GRACE risk score to predict the risk of acute coronary syndrome （ACS） during hospitalization. Methods Plasma FIB,D-D and GRACE risk score were measured in 90 patients with ACS and 23 healthy controls,the number of coronary artery lesions of ACS patients also was obtained. Results The results of FIB,D-D levels and GRACE risk score in ACS group were 2.77-0.79 g/L,1. 67±2.13 mg/L,147.19±32.50,respectively. Compared to controls, FIB, D-D and GRACE risk score in ACS group were significantly increased （t= 6. 256,6. 465, 10. 317,all P〈0. 001）. There were significant differences in plasma D-D and FIB levels in different risk stratification （F= 18. 475,9. 426,all P〈0. 001）. FIB （r=0. 485,P〈0. 000 1） and D-D （r=0. 357,P〈0. 000 6） levels were found positively related with GRACE risk score. Conclusion Pasma FIB ,D-D levels and GRACE risk score were increased in ACS group. FIB and D-D can be used as indicators to predict the risk stratification for ACS patients, and D-D was better than FIB.

关 键 词：急性冠脉综合征 纤维蛋白原 D-二聚体 全球急性冠状动脉事件注册评分 

分 类 号：R543.3[医药卫生—心血管疾病] R446.112[医药卫生—内科学]