血清胰岛素与慢性肾脏病的相关研究及其应用价值  

Correlation of Serum Insulin and Chronic Kidney Disease and Its Application Value

作　　者：肖传宇[1] 王宁[1] 王小艳[1] 付小曼 陶锋[1] 谢强[1] 

机构地区：[1]枣阳市第一人民医院检验科,湖北枣阳441200

出　　处：《现代检验医学杂志》2017年第1期109-112,共4页Journal of Modern Laboratory Medicine

基　　金：湖北省卫生计生委科研项目(WJ2015Z098)

摘　　要：目的研究慢性肾脏病患者血清胰岛素水平变化及临床意义。方法以400例健康体检人员作为对照组,根据相应的病因将800例慢性肾脏病患者分为糖尿病肾病慢性肾衰竭组(425例)与非糖尿病肾病慢性肾衰竭组(375例),将糖尿病肾病慢性肾衰竭组分为1型糖尿病(105例)、2型糖尿病(135例)、妊娠期糖尿病(95例)、特殊糖尿病(90例),收集研究对象相关临床资料,测定尿素(Urea)、血肌酐(SCr)、空腹血糖(FPG)及空腹胰岛素(FIns),计算胰岛素敏感指数(ISI)和肾小球滤过率(GFR),处理分析数据。结果慢性肾脏病患者的Urea,Scr,FPG和FIns均显著高于正常健康人对照组(t=36.788,35.612,137.216,9.294,P值均为0.000)。三组研究对象的年龄、性别和BMI差异均不具有统计学意义(F=1,363,P=0.256;F=1.577,P=0.454;F=1.641,P=0.194)。比较不同类型糖尿病的慢性肾脏病患者,FIns较高和ISI较小的研究对象,GFR同样较小,各组间差异均具有统计学意义(F=12.01,P=0.000;F=3.891,P=0.009;F=3.774,P=0.011)。结论慢性肾脏病患者与血清胰岛素水平密切相关,检测患者的血清胰岛素水平能够更准确地把握疾病发展,预测治疗效果和预后情况。Objective To study serum insulin level change and its clinical significance in the patients with chronic kidney dis- ease （CKD）. Methods 800 cases of patients with chronic kidney disease were observed with 400 cases of healthy people as control group at the same time. According to whether there was a complication of diabetic, chronic nephropathy was divided into two groups：diabetic nephropathy chronic renal failure group （425 cases） and non-diabetic nephropathy chronic renal failure （375 cases）. According to the classification standard, chronic renal failure and the diabetic nephropathy group was di- vided into four groups： type 1 diabetes （105 cases）, type 2 diabetes （135 cases）, gestational diabetes （95 cases）, diabetes with other reasons （90 cases）. Relevant clinical information was collected, including age, gender, height, weight, and the cor- responding body mass index （BMI） was calculated based on height and weight. After some laboratory examinations, related parameters of the research were collected, including object of urea（Urea）, serum creatinine （SCr）, fasting plasma glucose （FPG）, fasting insulin （Fins）. According to the corresponding formula,insulin sensitive index （ISI） and glomerular filtration rate （GFR） were calculated based on the above parameters. Statistical comparison was made after collection. Results Urea, Scr, FPG and Fins of the patients with chronic kidney disease were significantly higher than those of normal control group （t =36. 788,35. 612,137. 216,9. 294;all P = 0. 000 respectively）. Age, gender and BMI calculatedfrom height and weight in three groups had differences, but they were not statistically significan.t （ F= 1,363, P = 0. 256 ; F = 1. 577, P = 0. 454 ; F =1. 641 ,P=0. 194）,and had no effect on the occurrence of chronic kidney disease development. Comparison of patients with different types of diabetes and chronic kidney disease, when a group had higher Fins and lower ISI, it also had a smaller GFR, and the d

关 键 词：慢性肾脏病 糖尿病 高胰岛素血症 胰岛素抵抗 肾小球滤过率 胰岛素敏感指数 

分 类 号：R692[医药卫生—泌尿科学]