赤芍组分SY-002抗雌孕激素诱导大鼠子宫肌瘤作用的研究  

Paeonia lactiflora Components SY-002 on Anti-Hysteromyoma Effects in Rats Induced by Estrogen and Progesterone

作　　者：魏新智[1] 闵冬雨[1] 王清华[1] 张立德[2] 孙科峰[1] 吴景东[2] 

机构地区：[1]辽宁中医药大学附属医院,辽宁沈阳110032 [2]辽宁中医药大学,辽宁沈阳110847

出　　处：《中华中医药学刊》2017年第2期405-407,I0010,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：辽宁省科技厅中药有效复方再评价重点实验室项目(F10-207-1-00)

摘　　要：目的:研究赤芍组分SY-002对大鼠子宫肌瘤的治疗作用。方法:以雌激素和孕酮联合诱导大鼠子宫肌瘤为模型,设正常对照组、模型组、赤芍组分SY-002低(10 mg·kg^(-1)·d^(-1))、赤芍组分SY-002中(30 mg·kg^(-1)·d^(-1))、赤芍组分SY-002剂量高三个剂量组(100 mg·kg^(-1)·d^(-1)),灌胃给药,2次/d;以子宫系数、病理形态学、子宫平滑肌厚度、血清中雌激素、孕酮含量为观察指标。结果:赤芍组分SY-002对子宫肌瘤有明显抑制作用,病理形态学改善作用明显,对血清雌激素均有不同程度的抑制作用。结论:赤芍组分SY-002对子宫肌瘤具有一定的治疗作用。Objective ： To study the effect of paeoniflorin on anti - hysteromyoma in rat models induced by estrogen and progesterone. Methods ： The rat models of hysteromyoma induced by estrogen and progesterone were used and divided into normal group, model group, paeoniflorin group （ 10,30,100 mg · kg - 1 · d - 1 ） , administered orally,2 times/d, And uterine coefficient, pathological ehanges and uterine thickness of smooth muscle, serum levels of estrogen and progesterone were observed. Results： Paeoniflorin decreased the uterus coefficient and serum estrogen and improved pathological changes. Conclusion： Paeoniflorin could inhibit uterine fibroids in the rat models induced by estrogen and progesterone in a certain extent.

关 键 词：赤芍 子宫肌瘤 雌激素 孕激素 

分 类 号：R285.5[医药卫生—中药学]