医院非淋球菌性尿道炎患者支原体感染和耐药状况研究  

Mycoplasma infection and drug resistance of patients with non gonococcal urethritis in hospital

作　　者：方菊[1] 曹正英[2] 吉文倩 黎家华[1] 陈垂婉[1] 

机构地区：[1]三亚市妇幼保健院检验科,海南三亚572000 [2]三亚市妇幼保健院妇产科,海南三亚572000

出　　处：《中华医院感染学杂志》2017年第3期510-513,共4页Chinese Journal of Nosocomiology

基　　金：海南省卫生厅科技计划项目(Z2012283)

摘　　要：目的探究医院非淋球菌性尿道炎患者支原体感染和耐药状况,以期临床治疗提供参考。方法选取2013年1月-2015年12月医院收治152例非淋球菌性尿道炎患者为研究对象,均进行支原体培养和药敏检测,并分析支原体对各类抗菌药物的耐药性变迁。结果 2013-2015年间支原体培养阳性率逐年升高,但各类支原体所占比例无显著变化,大部分为Uu,其次为Uu+Mh,Mh最少;2013年-2015年间不同支原体来源由高到低为宫颈分泌物、男性尿道分泌物;女性支原体感染率显著高于男性;支原体感染率最高的年龄段为21~30岁,其次为31~40岁,差异有统计学意义(P<0.05);2013-2015年Uu+Mh对多西环素、米诺环素、克雷霉素、交沙霉素,Uu对环丙沙星的耐药率变化差异无统计学意义;2013-2015年Uu+Mh和Uu对多诺环素、环酯红霉素、阿奇霉素、克拉霉素、罗红霉素、红霉素、左氧氟沙星、司帕沙星、甲砜霉素等耐药性逐年增高,差异有统计学意义(P<0.05)。结论支原体感染多发于年龄21~30岁女性,且发病率逐年增高,对各类常用抗菌药物的耐药性也逐年增高,多西环素、米诺环素、交沙霉素成为治疗的首选药物,临床中可依据支原体培养和药敏检测选择适当的抗菌药物进行治疗。OBJECTIVE To investigate the mycoplasma infection and drug resistance of patients with non gonococcal urethritis in hospital,so as to provide references for clinical treatment.METHODS A total of 152 cases of non gonococcal urethritis patients in a hospital from Jan.2013 to Dec.2015 were selected as research objects.The mycoplasma culture and drug susceptibility testing were carried out,and changes of the drug resistance of mycoplasma to various types of antimicrobials were analyzed.RESULTS The positive rate of mycoplasma culture increased year by year from 2013 to 2015,but the proportion of all kinds of mycoplasma did not change significantly,most of them were Uu,followed by Uu ＋ Mh,and Mh was the least.From 2013 to 2015,different sources of mycoplasma from high to low were cervical secretions and male urethral secretions.Mycoplasma infection rate was significantly higher in women than men,and was the highest among those aged 21-30 years old,followed by 31-40 years old,and the difference was significant（P0.05）.From 2013 to 2015,there was no significant difference in the resistant rates of Uu＋Mh to doxycycline,minocycline,doxycycline,and josamycin,and Uu to ciprofloxacin.The resistant rates of Uu＋Mh and Uu to doxorubicin,erythromycin cydocarbonate,azithromycin,clarithromycin,roxithromycin,erythromycin,levofloxacin,sparfloxacin,and thiamphenicol increased year by year,and the difference was significant（P0.05）.CONCLUSION Mycoplasma infection is more common in women aged 21-30 years,the incidence is increasing year by year,and the resistance to the various types of commonly used antimicrobial drugs is increasing year by year.Doxycycline,minocycline,and josamycin become the first choice in clinic,and it can select appropriate antibiotics for treatment based on mycoplasma culture and drug susceptibility.

关 键 词：非淋球菌性尿道炎 支原体感染 耐药状况 

分 类 号：R378.106[医药卫生—病原生物学]