高危型HPV感染对宫颈病变组织Th1Th2相关指标表达的影响研究  

Influence of high risk type HPV infection for the expression of cervical lesion tissue Th1Th2 related indexes

作　　者：杨东晓[1] 李红娟[1] 田晓娜[1] 牛庆玲[1] 李红雨[2] 

机构地区：[1]郑州大学附属郑州中心医院妇产科,河南郑州450001 [2]郑州大学第三附属医院妇科,河南郑州450001

出　　处：《中华医院感染学杂志》2017年第3期657-659,共3页Chinese Journal of Nosocomiology

基　　金：河南省卫生计生委科技攻关项目(201303090)

摘　　要：目的研究与观察高危型HPV感染对宫颈病变组织Th1Th2相关指标表达的影响,以了解高危型HPV感染对该类患者免疫状态的影响。方法选取2015年3月-2016年4月65例高危型HPV感染患者为A组,65例低危型HPV感染患者为B组,65名健康同龄妇女为C组,检测及比较3组受试者的宫颈组织Th1Th2相关指标表达情况,然后比较A组不同病毒载量及分型患者的Th1Th2相关指标表达情况。结果 A组的组织IFN-γ阳性表达率为13.85%,明显低于B组21.54%及C组38.46%,B组则低于C组;A组的组织IL-4、IL-10、IL-13及TNF-α的阳性表达率为36.92%、41.54%、40.00%及49.23%,均高于B组23.08%、26.15%、23.08%、27.69%及C组1.54%、3.08%、1.54%、4.62%,B组则高于C组;A组不同病毒载量患者的阳性表达率也存在明显差异(P<0.05),但不同分型患者的阳性表达率无明显差异。结论高危型HPV感染患者宫颈病变组织Th1Th2相关指标表达较高,且病毒载量对其表达水平也有较大影响,因此应重视对高危型HPV感染患者上述指标的监测与改善。OBJECTIVE To study and observe the influence of high risk type HPV infection for the expression of cervical lesion tissue Th1Th2 related indexes,in order to understand the influence of high risk type HPV infection for the immune state.METHODS A total of 65 patients with high risk type HPV infection from Mar.2015 to Apr.2016 were selected as group A,65 patients with low risk type HPV infection were selected as group B,and 65 healthy women of the same ages were selected as group C.The expression situation of cervical tissue Th1Th2 related indexes of the three groups were detected and compared,and the expression situation of Th1Th2 related indexes of group A with different viral loads and types were compared too.RESULTS The positive rate of tissue IFN-γof group A was 13.85%,which was lower than 21.54% of group B and 38.46% of group C,and the positive rate of group B was lower than that of group C.The positive rates of tissue IL-4,IL-10,IL-13 and TNF-αof group A were 36.92%,41.54%,40.00% and 49.23%,which were all higher than 23.08%,26.15%,23.08%,27.69% of group B and 1.54%,3.08%,1.54%,4.62% of group C,and the positive rates of group B were higher than those of group C.The positive rates of group A with different viral loads had significant differences（P〈0.05）,while the positive rates of group A with different types had no significant differences.CONCLUSION The expression of cervical lesion tissue Th1Th2 related indexes of patients with high risk type HPV infection are higher,and the influence of the viral loads for the expression levels are great,so those indexes of patients with high risk type HPV infection should pay attention for their monitoring and improvement.

关 键 词：高危型HPV感染 宫颈病变组织 Th1Th2相关指标表达 

分 类 号：R373[医药卫生—病原生物学]