祁菊叶化学成分的分离与结构鉴定  

Study on the constituents of Chrysanthemum morifolium Ramat. Qiju leaves

作　　者：瞿璐[1] 刘艳霞[1] 李建良[1] 布淑阳 王涛[1] 张祎[1] QU Lu LIU Yan-xia LI Jian-liang BU Shu-yang WANG Tao ZHANG Yi(Tianjin University of Traditional Chinese Medicine, Key Laboratory of Traditional Chinese Medicinal Chemistry and Analytical Chemistry of Tianjin, Tianjin 300193, China)

机构地区：[1]天津中医药大学,天津市中药化学与分析重点实验室,天津300193

出　　处：《天津中医药大学学报》2017年第1期57-60,共4页Journal of Tianjin University of Traditional Chinese Medicine

基　　金：大学生创新创业训练计划(201510063003)

摘　　要：[目的]为缓解生态压力,扩大药用菊花的临床适用范围,对祁菊非药用部位叶70%乙醇提取物的化学成分进行研究。[方法]利用多种色谱法,如正相硅胶、反相ODS、Sephadex LH-20及高效液相色谱等进行分离纯化,并通过理化性质及波谱分析鉴定化合物结构。[结果]从祁菊叶70%乙醇提取物中分离鉴定了6个单体化合物,分别为茵芋苷(1),菊苣苷(2),苯甲基-6-O-β-D-吡喃葡萄糖苷(3),苄醇-O-[β-D-吡喃葡萄糖-(1→6)]-β-D-吡喃葡萄糖苷(4),icariside D1(5),松柏苷(6)。[结论]化合物4、5为首次从菊属植物中分离得到。[Objective] To alleviate the ecological pressures and expand clinical application scope of Chrysanthemum genus plants, we study the chemical constituents of Chrysanthemum morifolium Ramat. Qiju leaves.[Methods] The chemical compounds were isolated through kinds of chromatorgraphies such as Sephadex LH-20,ODS, Silica gel and PHPLC chromatorgraphies and identified by chemical and spectral analysis（1H,13 C NMR, 1H1 H COSY, HMQC, HMBC, UV, IR, MS）. [Results] Six compounds were obtained and identified as skimmin（1）,cichoriin（2）, benzyl-O-β-D-glucopyranoside（3）, benzyl alcohol-O-β-D-glucopyranosyl-（1→6）-β-D-glucopyranoside（4）, icariside D1（5）, and coniferin（6）. [Conclusion] Compounds 4, 5 were obtained from Chrysanthemum genus firstly.

关 键 词：祁菊叶 化学成分 结构鉴定 

分 类 号：R284[医药卫生—中药学]