缬沙坦氨氯地平复方制剂治疗原发性高血压对心肾功能的影响  

作　　者：王璞[1] 王琦[1] 李涤病[1] 

机构地区：[1]浙江省宁波市第六医院心血管内科,315040

出　　处：《浙江临床医学》2017年第2期300-301,共2页Zhejiang Clinical Medical Journal

摘　　要：目的探讨缬沙坦氨氯地平复方制剂治疗原发性高血压对心肾功能的影响。方法将100例原发性高血压患者按照随机数字表法分为观察组和对照组，每组各50例。观察组给予缬沙坦氨氯地平片口服治疗，对照组给予苯磺酸氨氯地平片口服治疗，两组患者均观察24周。观察两组患者治疗前后血压及心肾功能变化，并观察药物相关的不良反应。结果两组患者治疗后收缩压及舒张压均较治疗前显著下降（P〈0．01），观察组收缩压及舒张压均显著低于对照组（P〈0．01）；两组患者治疗后左室射血分数（LVEF）、每分钟输出量（CO）、左室舒张早期峰值流速（E）／左室舒张晚期峰值流速（A）均较治疗前明显提高（P〈0．01，P〈0．05），观察组均明显高于对照组（P〈0．05，P〈0．01）；两组患者治疗后尿微量白蛋白（mALB）、血清胱抑素C（CysC）均较本组治疗前明显下降（P〈0．01，P〈0．05），观察组mALB、CysC均明显低于对照组（P〈0．叭，P〈0．05）；观察组药物不良反应发生率为8．0％，明显低于对照组的24．0％（P〈0．05）。结论缬沙坦氨氯地平复方制剂治疗原发性高血压可有效提高降压效果，对心肾功能有显著的保护作用，同时还能减少药物不良反应，临床应用优势较为显著。Objective To explore the effect of treating primary hypertension with valsartan amlodipine compound preparation on cardiac and renal function. Methods 100 patients with primary hypertension were divided into observation group and control group according to random number table with 50 patients in each group. Patients in observation group were treated with oral medication of valsartan amlodipine tablet and those of control group were treated with oral medication of amlodipine besylate. Patients of two groups were followed up for 24 weeks. Changes of blood pressure and cardiac and renal function of patients in two groups before and after the treatment as well as medicine-related untoward effect were observed. Results Systolic pressure and diastolic pressure of patients in two groups were significantly lower than those before the treatment （ P〈0.01 ） . And systolic pressure and diastolic pressure of patients in observation group were also significantly lower than those of patients in control group （ P〈0.01 ） . Left ventricular ejection fraction （ LVEF ） , cardiac output （ CO ） and left ventricular peak velocity of early diastole stage （ E ） and advanced diastole stage （ A ） of patients in two groups after the treatment were significantly higher than those before the treatment. （ P〈0.01, P〈0.05 ） And those indexes of observation group were significantly of those of control group. （P〈0.05, P〈0.01 ） Microalbuminuria （mALB） and cystatin C （ CysC ） of patients in two groups after the treatment were significantly lower than those of patients before the treatment （P〈0.01, P〈0.05 ） . And microalbuminuria （ mALB ） and cystatin C （ CysC ） of patients in observation group were significantly lower than those of control group （ P〈0.01, P〈0.05 ） . The occurrence rate of adverse drug reaction of patients in observation group was 8.0%, which is significantly lower than that of patients in control group of 24.0% （ P〈0.05 ） . Conclusions Treating primar

关 键 词：缬沙坦氨氯地平片 苯磺酸氨氯地平片 原发性高血压 心肾功能 

分 类 号：R544.1[医药卫生—心血管疾病]