HBV感染者血清中HBeAg，HBeAb与Pre-S1抗原的关系  

Relationship between HBeAg, HBeAb and Pre-S1 antigen in serum of HBV infected persons

作　　者：罗志达[1] 

机构地区：[1]梅州市人民医院检验科,广东梅州514031

出　　处：《医学检验与临床》2016年第9期30-32,共3页Medical Laboratory Science and Clinics

摘　　要：目的：探讨HBV感染者血清中HBeAg，HBeAb与Pre-S1抗原的相关性及其临床意义。方法：选取2015年1月-12月HBV感染者血清1428例，采用酶联兔疫吸附法（ELISA）检测HBsAg，HBsAb，HBeAg，HBeAb，HBcAb及Pre-S1抗原，应用SPSS17．0统计软件对HBeAg，HBeAb与Pre-S1抗原进行χ2检验分析其相关性。结果：在1428例HBV感染者中HBeAg阳性者216例，HBeAg阴性者1212例，HBeAg阳性者与阴性者Pre—S1抗原阳性率分别为94．4％和61．5％，HBeAg阳性者中Pre—S1抗原阳性率明显高于HBeAg阴性者，两者比较差异有统计学意义（χ2=89．43，P〈0．05）。在1212例HBeAg阴性者中HBeAb阳性者960例，HBeAb阴性者252例。Pre-S1抗原阳性率分别为57．5％和76．6％，HBeAb阳性者中Pre-S1抗原阳性率低于HBeAb阴性者，两者比较差异有统计学意义（χ2=36．18，P〈0．05）。结论：血清HBeAg，HBeAb与Pre—S1抗原存在相性。Pre—S1抗原阳性代表HBV复制严重，具有较强的传染性，Pre-S1抗原阴性可作为提示乙肝患者传染性相对较弱，感染趋于恢复病情趋向好转的标志。Pre-S1抗原与HBeAg、HBeAb联合检测能更好的反映HBV的复制情况、传染性和疾病的预后。Objective： To investigate the relationship between HBeAg, HBeAb and Pre-S1 antigen in HBV infected persons and their clinical significance. Methods： 1428 serum from patients with HBV infection from January to December 2015 were selected. Enzyme linked immuno sorbent assay （ELISA） was used to detect HBsAg, HBsAb, HBeAg, HBeAb, HBcAb and Pre-Sl antigen and the relevance among HBeAg, HBeAb and Pre-sl antigen was verified and analyzed with the χ2 method using the statisti- cal software named SP-SS/7.0.Results： 216 cases of 1428 patients with HBV infection were HBeAg positive, 1212 cases were HBeAg negative. Pre-s/ antigen positive rate of HBeAg positive and negative persons were 94.4% and 61.5% respectively, Pre-sl antigen positive rate of HBeAg positive patients was significantly higher than that of HBeAg negative patients, the difference has statis- tical significance （χ2 =89.43 P〈0.05） . 960 cases of 1212 HBeAg negative patients were HBeAb positive, 252 cases were HBeAb negative. Pre-S1 antigen positive rate of HBeAb positive and negative persons were 57.5% and 76.6% respectively, Pre-sl antigen positive rate in HBeAb positive patients was lower than that of HBeAb negative, the difference has statistical significance （χ2 =36.18 P〈0.05） . Conclusion： HBeAg and HBeAb are related to serum Pre-S/ antigen. Pre-S1 antigen positive means that HBV were copying seriously and had strong infectiousness. Pre-S1 antigen negative can be used as a sign of relatively weak HBV infection which tends to restore. Combined detection of Pre-S1 antigen, HBeAb and HBeAg can effectively reflect the replication and the prognosis of HBV infection diseases.

关 键 词：HBEAG HBEAB Pre—S1抗原 HBV 

分 类 号：R446.62[医药卫生—诊断学]