Epstein-Barr病毒感染及相关皮肤疾病  

Epstein-Barr Virus Infection and Its Related Cutaneous Diseases

作　　者：徐子刚[1] 徐教生[1] 

机构地区：[1]首都医科大学附属北京儿童医院皮肤科,北京100045

出　　处：《中国医学文摘（皮肤科学）》2017年第1期55-64,共10页China Medical Abstracts(Dermatology)

摘　　要：EB病毒是一种人类疱疹病毒,其原发感染多无临床症状或导致传染性单核细胞增多症。原发感染后,EB病毒终身潜伏于健康人体的B淋巴细胞。但是,部分感染者发展为慢性活动性EB病毒感染,或者出现一些EB病毒相关的恶性疾病,如Burkitt's淋巴瘤、鼻咽癌、霍奇金淋巴瘤、牛痘样水疱病样淋巴细胞增生性疾病、NK/T细胞淋巴瘤、皮下脂膜炎样T细胞淋巴瘤、血管免疫母细胞T细胞淋巴瘤。本文将详述EB病毒感染的特点、机制,并讨论EB病毒相关皮肤疾病的临床、病理特征。Epstein-Barr virus （EBV） is a human herpes virus. Primary EBV infection is usually asymptomatic or leads to infectious mononucleosis. After primary infection, the virus remains latent infection in B lymphocytes in healthy humans permanently. However, some individuals may develop to chronic active EBV infection or EBV-related malignancies,such as Burkitt＇s lymphoma, nasopharyngeal carcinoma, Hodgkin＇s disease, hydroa vacciniforme lymphoproliferative disorder, NK/T cell lymphoma, subcutaneous panniculitis-like T-cell lymphoma and angioimmunoblastic T-cell lymphoma. This review provides a comprehensive overview of the epidemiology, pathophysiology of EBV infection. The EBV-related skin disorders are reviewed with an emphasis on clinicopathological features.

关 键 词：EB病毒 慢性活动性EB病毒感染 牛痘样水疱病 淋巴细胞增生性疾病 淋巴瘤 

分 类 号：R752[医药卫生—皮肤病学与性病学] R373.9[医药卫生—临床医学]