人类疱疹病毒8型相关性疾病的研究进展  

Research Progress of the Correlation Disease of Human Herpes Virus 8

作　　者：吴秀娟[1] 普雄明[1] 

机构地区：[1]新疆维吾尔自治区人民医院皮肤科,新疆乌鲁木齐830001

出　　处：《中国医学文摘（皮肤科学）》2017年第1期79-83,共5页China Medical Abstracts(Dermatology)

摘　　要：人类疱疹病毒8型(HHV-8)又称卡波西肉瘤疱疹病毒(KSHV),发现于HIV的卡波西肉瘤患者,该病毒的潜伏性和裂解性是感染后引起卡波西肉瘤的重要特性,通过DNA,RNA及蛋白表达等分子生物学研究,HHV-8的阳性率达70%以上。随后对HHV-8的某些基因亚型的研究发现,A-Z六种亚型及24个以上分支,这些亚型与卡波西肉瘤的侵袭性有着重要联系。非卡波西肉瘤中,HHV-8通过抑制抑癌基因表达、激活癌基因、干扰细胞生长分化相关信号等机制影响细胞生长周期调控等功能,诱导细胞恶性转化。Human herpes virus 8（HHV-8）,also known as kaposi＇s sarcoma herpesvirus（KSHV）,is found in human immunodeficiency virus infection（HIV）.The latent and lytic character of the virus is a significant point that caused Kaposi＇s Sarcoma after infection.Through DNA,RNA and protein expression of molecular biology research,positive rate of HHV-8 expression is more than 70%.It is found that there are six sub-types（a-z） and 24 branchessome about sub-type of HHV-8 gene.And there is a significant velationship between these sub-types and invasiveness of Kaposi＇s Sarcoma.Non-Kaposi＇s Sarcoma,the HHV-8 affected cell cycle regulation and induced cell malignant transformation by inhibiting expression of tumor suppressor gene,acting the oncogene and interfering with related signal mechanism of cell growth and Differentiation.

关 键 词：人类疱疹病毒8 卡波西肉瘤 恶性疾病 

分 类 号：R752.5[医药卫生—皮肤病学与性病学]