1例哌拉西林他唑巴坦致血小板减少的药学监护  

Pharmaceutical Care for A Case of Piperacillin-Tazobactam Induced Thrombocytopenia

作　　者：李祚勇[1] 吴晓鹏[2] 王金平[3] 严金玲[1] LI Zuoyong WU Xiaopeng WANG Jinping YAN Jinling(The First Affiliated Hospital of Gannan Medical College, Ganzhou , Jiangxi 341000, China Bao＇ an District of Shenzhen City Songgang People＇s Hospital, Shenzhen , Gtumgdong 518105, China Shenzhen Second People＇s Hospital, Shenzhen, Guangdong 518035, China)

机构地区：[1]赣南医学院第一附属医院,江西赣州341000 [2]深圳市宝安区松岗人民医院,广东深圳518105 [3]深圳市第二人民医院,广东深圳518035

出　　处：《今日药学》2016年第12期882-884,共3页Pharmacy Today

摘　　要：目的加强药物不良反应监护,让医师和药师认识到药学监护的重要性,保证临床用药安全。方法介绍1例81岁肺部感染女性患者,因使用哌拉西林他唑巴坦4.5 g静滴(q8 h)抗感染治疗14 d后,导致其血小板严重减少,双侧大腿内侧出现大片淤血斑。临床药师在治疗过程中及时提出停用哌拉西林他唑巴坦换用其他抗菌药物的合理性建议。结果停用哌拉西林他唑巴坦后,血小板恢复正常,淤血斑完全消失。结论临床药师参与临床药物治疗实践,有利于协助医生提高药物治疗水平及保证患者的用药安全。OBJECTIVE To strengthen the monitoring adverse drug reaction, let the doctors and pharmacists to recognize the importance of pharmaceutical care to ensure the clinical medication safety. METHODS One case of 81-year-old woman with pulmonary infection using piperacillin tazobactam 4.5 g （ q8 h ） intravenous anti-infective therapy was described, medication-induced platelet severely reduced after 14 d,the inside of the thighs on both sides had been large congestion spots. During the treatment, clinical pharmacists promptly presented deactivate piperacillin tazobactam change Cefoperazone sulbactam reasonable suggestions. RESULTS The discontinuation of piperacillin tazobactam, platelet count returned to normal, congestion spots completely disappeared. CONCLUSION Clinical pharmacists should participate in the clinical drug therapy practice, to help doctors improve the level of drug treatment, and to ensure the medication safety of patients.

关 键 词：临床药师 哌拉西林他唑巴坦 血小板减少 药学监护 

分 类 号：R97[医药卫生—药品]