Changes in oxygen saturation can not help diagnose acute mountain sickness(AMS)： ascending to Lhasa on the Qinghai-Tibet train  

作　　者：Jun-bo AN Hao-ran GU Yu WU Yong-jun LUO 

机构地区：[1]Department of Military Medical Geography, College of High Altitude Military Medicine, Third Military Medical University, Chongqing 400038, China [2]Battalion 5 of Cadet Brigade, Third Military Medical University, Chongqing 400038, China [3]Key Laboratory of High Altitude Medicine (Ministry of Education), Third Military Medical University, Chongqing 400038, China [4]The 12th hospital of PLA, Kashi 844200, China

出　　处：《中国应用生理学杂志》2016年第6期519-524,共6页Chinese Journal of Applied Physiology

基　　金：supported by the National Natural Science Foundation of China(81372125)

摘　　要：Objective: Acute mountain sickness(AMS) is a common condition in individuals who ascend to altitudes over 2 500 m. There is no measurements that can reliably predict or diagnose this condition. We therefore determined whether pulse oximetry data are associated with the development of AMS and can help diagnose AMS. Methods: We studied 58 young male undergraduates who traveled from Chongqing(300 m) to Lhasa(3 658 m) by train. We collected data on the ascent profiles and AMS symptoms based on the Lake Louise Score(LLS). The resting arterial oxygen saturation(R-Sp O2) and pulse rate were then measured using finger pulse oximetry. Results: In Golmud(2 800 m) and Tanggula(5 200 m), R-SpO_2 was significantly lower in the AMS group than in the group without AMS(P<0.05). However, upon arrival in Lhasa(3 658 m), the R-SpO_2 was higher in the AMS group than in the non-AMS group(P<0.05). In Tanggula, the change in the SpO_2(CR-SpO_2) in the AMS group was higher than that in the non-AMS group(P<0.05). But in Lhasa, the CR-SpO_2 in the AMS group was lower than that in the non-AMS group(P<0.05). We also monitored heart rate(HR) throughout the study. In Xining(2 200 m) and Golmud, the HRs in the AMS group were higher than those in the non-AMS group. However, the HRs in the AMS group were lower than those in the non-AMS group in Tanggula and Lhasa. Conclusion: Based on the results of this study, the R-SpO_2 graph was not consistent. We can thus conclude that the utility of SpO_2 remains limited in the diagnosis of AMS. The results suggest that using pulse oximetry to diagnose AMS is not valuable in people ascending to Lhasa on the Qinghai-Tibet train.Objective： Acute mountain sickness（AMS） is a common condition in individuals who ascend to altitudes over 2 500 m. There is no measurements that can reliably predict or diagnose this condition. We therefore determined whether pulse oximetry data are associated with the development of AMS and can help diagnose AMS. Methods： We studied 58 young male undergraduates who traveled from Chongqing（300 m） to Lhasa（3 658 m） by train. We collected data on the ascent profiles and AMS symptoms based on the Lake Louise Score（LLS）. The resting arterial oxygen saturation（R-SpO2） and pulse rate were then measured using finger pulse oximetry. Results： In Golmud（2 800 m） and Tanggula（5 200 m）, R-SpO2 was significantly lower in the AMS group than in the group without AMS（P〈0.05）. However, upon arrival in Lhasa（3 658 m）, the R-SpO2 was higher in the AMS group than in the non-AMS group（P〈0.05）. In Tanggula, the change in the SpO2（CR-SpO2） in the AMS group was higher than that in the non-AMS group（P〈0.05）. But in Lhasa, the CR-SpO2 in the AMS group was lower than that in the non-AMS group（P〈0.05）. We also monitored heart rate（HR） throughout the study. In Xining（2 200 m） and Golmud, the HRs in the AMS group were higher than those in the non-AMS group. However, the HRs in the AMS group were lower than those in the non-AMS group in Tanggula and Lhasa. Conclusion： Based on the results of this study, the R-SpO2 graph was not consistent. We can thus conclude that the utility of SpO2 remains limited in the diagnosis of AMS. The results suggest that using pulse oximetry to diagnose AMS is not valuable in people ascending to Lhasa on the Qinghai-Tibet train.

关 键 词：脉搏血氧饱和度 诊断系统 AMS 高原病 拉萨 火车 西藏 青海 

分 类 号：U212.2[交通运输工程—道路与铁道工程] TP212[自动化与计算机技术—检测技术与自动化装置]