长链非编码RNA UCA1在神经胶质瘤中的表达及与临床预后的关系  

The expression of lncRNA UCA1 in glioma and its effect on the Prognosis of glioma

作　　者：蔡正华[1] 赵伟[1] 陈佳磊[1] 

机构地区：[1]南通市第一人民医院神经外科,江苏226001

出　　处：《交通医学》2016年第6期574-576,共3页Medical Journal of Communications

摘　　要：目的：探讨UCA1在神经胶质瘤组织中的表达及其与临床预后的关系。方法：实时荧光定量PCR法检测64例神经胶质瘤组织（WHOⅠ～Ⅱ级22例,Ⅲ～Ⅳ级42例）及10例对照正常脑组织中UCA1 mRNA的表达,分析其与神经胶质瘤患者临床病理特征及预后之间的关系。结果：神经胶质瘤组织中UCA1 mRNA的表达水平明显高于对照正常脑组织（P〈0.001）;UCA1的表达与患者的WHO分级明显相关（P〈0.05）,而与患者的年龄、性别、肿瘤大小和KPS评分等无关（P〉0.05）。结论：lncRNA UCA1与胶质瘤恶性程度及预后密切相关,可能成为胶质瘤预后判断的一个独立因子及治疗新靶点。Objective：To discuss the expression of lncRNA UCA1 in glioma and its effect on the Prognosis of glioma. Method：LncRNA UCA1 expressions in 64 glioma samples（GradeⅠ～Ⅱ in 22 cases and Grade Ⅲ～Ⅳ in 42 cases,according to WHO criteria） and 10 normal brain samples were detected by using real-time fluorescence quantitative PCR.On this basis, the correlations of UCA1 to clinicopathological characteristics and prognosis of glioma were assessed. Result：Lnc RNA UCA1 expression in the glioma samples was obviously higher as compared with the normal brain samples（P〈0.001）, and the expression was significantly correlated to grading of the tumors（P〈0.05）. However, lncRNA UCA1 expression was not correlated to age, gender, tumor size and KPS score（P〉0.05）. Conclusion：UCA1 may serve as an independent prognostic indicator and a novel therapeutic target for glioma.

关 键 词：胶质瘤 长链非编码RNA 尿路上皮癌胚抗原1 预后 

分 类 号：R651.19[医药卫生—外科学]