A Simple and Novel Electrochemical Sensor Based on Phosphomolybdic-Polypyrrole Film Modified Electrode for Highly Sensitive Detection of Cholic Acid  

作　　者：Lifang Fan Xinxin Tian Shaomin Shuang Chuan Dong 

机构地区：[1]Institute of Environmental Science, Shanxi University, Taiyuan, Sharnxi 030006, China [2]Department of Chemistry and Chemical Engineering, Shanxi University, Taiyuan, Shanxi 030006, China

出　　处：《Chinese Journal of Chemistry》2016年第11期1177-1182,共6页中国化学（英文版）

基　　金：This work was supported by the Natural Science Foundation of Shanxi Province, China （No. 201601D202008） and the Joint Funds of the National Natural Science Foundation of China （No. U 1510103）.

摘　　要：A simpe electrochemical sensor for detection of cholic acid （CA） was designed by modifying phosphomolybdate （PMol2） doped polypyrrole （PPy） film on glassy carbon electrode （PMo12-PPy/GCE）. The electrochemical behavior of CA on PMo12-PPy/GCE was investigated by cyclic voltammetry and 0.5 order differential voltammetry. The results indicated that CA had high inhibitory activity toward the peak currents of PMo12-PPy/GCE. The reduction peak currents were linearly related to the logarithmic value of the concentration of CA from 1.0 × 10^- 7 to 1.0 × 10^-3 mol/L with a low detection limit of 1.0 × 10^- 8 mol/L. The developed sensor exhibited excellent sensitivity, selectivity and stability for detection of CA, and it could be successfully applied to detect the level of CA in the urine samples. Moreover, the response mechanism of CA on the PMo12-PPy/GCE was discussed in detail.A simpe electrochemical sensor for detection of cholic acid （CA） was designed by modifying phosphomolybdate （PMol2） doped polypyrrole （PPy） film on glassy carbon electrode （PMo12-PPy/GCE）. The electrochemical behavior of CA on PMo12-PPy/GCE was investigated by cyclic voltammetry and 0.5 order differential voltammetry. The results indicated that CA had high inhibitory activity toward the peak currents of PMo12-PPy/GCE. The reduction peak currents were linearly related to the logarithmic value of the concentration of CA from 1.0 × 10^- 7 to 1.0 × 10^-3 mol/L with a low detection limit of 1.0 × 10^- 8 mol/L. The developed sensor exhibited excellent sensitivity, selectivity and stability for detection of CA, and it could be successfully applied to detect the level of CA in the urine samples. Moreover, the response mechanism of CA on the PMo12-PPy/GCE was discussed in detail.

关 键 词：PHOSPHOMOLYBDATE polypyprrole cholic acid 0.5 order differential voltammetry 

分 类 号：O613.62[理学—无机化学] TP212.2[理学—化学]