Selective Synthesis of 1,2-Diarylpyrrolo[3,4-b]pyridine-5,7- diones via Cyclization Reaction of β-Enamino Imides with Cinnamaldehydes  

作　　者：Yanhong Jiang Chaoguo Yan 

机构地区：[1]College of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou, Jiangsu 225002, China

出　　处：《Chinese Journal of Chemistry》2016年第12期1255-1262,共8页中国化学（英文版）

摘　　要：The novel 1,2-diaryl substituted pyrrolo[3,4-b]pyridine-5,7-diones were selectively synthesized in high yields by the base catalyzed cyclization reaction of 3-arylamino-l-methyl-lH-pyrrole-2,5-diones with cinnamaldehyde and its derivatives in acetonitrile at room temperature. However, when piperidinium trifluoroacetate was employed as catalyst, the reaction afforded a mixture of 1,2-diaryl and 1,4-diaryl substituted pyrrolo[3,4-b]pyridine-5,7-diones in comparable yields.The novel 1,2-diaryl substituted pyrrolo[3,4-b]pyridine-5,7-diones were selectively synthesized in high yields by the base catalyzed cyclization reaction of 3-arylamino-l-methyl-lH-pyrrole-2,5-diones with cinnamaldehyde and its derivatives in acetonitrile at room temperature. However, when piperidinium trifluoroacetate was employed as catalyst, the reaction afforded a mixture of 1,2-diaryl and 1,4-diaryl substituted pyrrolo[3,4-b]pyridine-5,7-diones in comparable yields.

关 键 词：pyrrolo[3 4-b]pyridine 1 2-dihydropyridine 1 4-DIHYDROPYRIDINE β-enamino amide CINNAMALDEHYDE 

分 类 号：O623.523[理学—有机化学] TQ925[理学—化学]