逍遥散及其类方抗抑郁机制研究进展  

Research progress of the antidepressant mechanism of Xiaoyao powder and its associated prescriptions

作　　者：周好波 姚璐[2] 路腾飞[1] 于泽胜 高树明[1] 高杉[1] 于春泉[1] 

机构地区：[1]天津中医药大学,硕士研究生300193 [2]北京军区总医院干四科

出　　处：《环球中医药》2017年第2期253-256,共4页Global Traditional Chinese Medicine

基　　金：国家自然科学基金(81273893);天津市科委自然科学基金(13JCZDJC31600)

摘　　要：抑郁症的现状已引起医学界的广泛重视,中医药治疗抑郁症相关文献所占比例也在逐年增加,其中针灸、中西医结合、中药方剂等方面关于治疗抑郁症的临床研究也取得了一定的成果。本文通过检索近五年相关文献,就逍遥散及其类方治疗抑郁症的主要作用机制展开综述,发现逍遥散及其类方可能通过影响单胺类神经递质、通路及受体的表达、下丘脑-垂体-肾上腺轴、肝组织代谢等发挥抗抑郁作用,其中,逍遥散干预BDNF/CREB信号通路的关键分子的表达与功能,改善应激损伤神经元状态,对逍遥散抗抑郁作用机制的研究有重要指导作用。The current situation of depression have attracted a lot of attention in the medical field.The proportion of literature of traditional Chinese medicine in treatment of depression also increased year by year. Many clinical researches of depression including acupuncture,Chinese and Western medicine and traditional Chinese medicine prescription had obtained certain achievements. Xiaoyao powder and its associated prescriptions may affect the depression by the ways of monoamine neurotransmitters,signal path and the expression of receptors,the hypothalamus-pituitary-adrenal axis and the metabolism of liver tissue. Xiaoyao powder is influence in the expression and function of the key molecule in the BDNF / CREB signaling pathway,and the function of improving the neuron state of stress injury have important guiding role inXiaoyao powder antidepressant mechanism studies.

关 键 词：逍遥散 抑郁症 机制 

分 类 号：R285.5[医药卫生—中药学]