TGF-β1受体1和2在TGF-β1调节细胞增殖中的作用  

TGF-β1 Receptor 1 and 2 in Regulating Cell Proliferation by TGF-β1

作　　者：王秋实[1,2] 李平[2] 

机构地区：[1]第三军医大学大坪医院野战外科研究所病理科,重庆400042 [2]第三军医大学大坪医院野战外科研究所分子生物学中心,重庆400042

出　　处：《中国生物化学与分子生物学报》2017年第2期122-127,共6页Chinese Journal of Biochemistry and Molecular Biology

基　　金：国家自然科学基金(No.30801195);重庆市前沿与应用基础研究项目(No.cstc2015jcyjA 0851)资助~~

摘　　要：转化生长因子β1(transforming growth factor-β1,TGF-β1)是一种多功能细胞因子,在细胞增殖、分化、伤口愈合和肿瘤生成转移等过程中均发挥重要调控作用。TGF-β1对细胞增殖的调节可因细胞类型、刺激剂量不同而不同,但其差异调节的机制还不清楚。现普遍认为,TGF-β1在TGFBR2/TGFBR1二聚体参与下通过经典的Smad信号通路抑制增殖,而通过非Smad信号通路促进细胞周期,但是机体是如何调控这种不同增殖调节作用转化的还不明确。TGFBR1和TGFBR2在细胞中的分布和比例变化可能是TGF-β1差异性调控细胞增殖作用的一个重要机制。Transforming growth factor beta 1 （TGF-β1） is a muhifunctional cytokine. TGF-β1 plays important roles in cell proliferation, differentiation, wound healing, tumor formation and metastasis. The regulatory mechanism of cell proliferation can be varied in different cell types, stimulating doses. But the specific mechanism remained unclear. Generally, the polymer of TGFBR2/TGFBR1 was involved in inhibiting the proliferation by TGF-β1, through the classic Smad signaling pathway. On the other hand, it was involved in promoting the cell cycle by TGF-β1, through the non-Smad signaling pathways. However, the mechanism regarding TGFBR2/TGFBR1 participates in this different regulation is not clear. The distribution and proportion changes of TGFBR1 and TGFBR2 in cells might be one of the reasons causing the regulation mechanism.

关 键 词：转化生长因子β1 TGF-β1受体1 TGF-β1受体2 细胞增殖 Smad信号系统 非Smad信号系统 

分 类 号：Q74[生物学—分子生物学]