厦门市某医院体检人群中有机氯农药暴露与胆石症发病的关联性研究  

Study on the correlation between organochlorine pesticide exposure and cholelithiasisamong physical examinees at a hospital in Xiamen City

作　　者：陈江慧 何洁[2] 陈静[1] 赖圳宾[2] 王新红[3] 李永玉[3] 于晓珊 程祺峻 刘惠芬[1] 彭雪琪 赵本华[1] 

机构地区：[1]分子疫苗学和分子诊断学国家重点实验室,厦门大学公共卫生学院预防医学系,福建厦门361102 [2]厦门市第二医院,福建厦门361021 [3]厦门大学环境与生态学院,福建厦门361102

出　　处：《现代预防医学》2017年第4期613-617,626,共6页Modern Preventive Medicine

基　　金：厦门市科技计划项目(3502Z20163006);厦门市集美区科技计划项目(20142C01);厦门大学校长基金(20720152012)

摘　　要：目的探讨厦门市第二医院体检人群中有机氯农药暴露与胆结石发生的关联及其发病危险因素。方法收集2015年2月-8月在医院健康体检人群中经B超确诊的新发胆囊结石患者100例,以同期参加体检的非胆囊结石者为对照,进行1∶2配比的病例对照研究。进行流行病学调查,采用气相色谱联用电子捕获器检测研究对象外周血中有机氯农药水平。应用多因素条件Logistic回归模型分析有机氯农药与胆囊结石发病的关系。结果病例组血清中α-HCH残留水平高于对照组,差异有统计学意义;Logistic回归分析非酒精性脂肪肝、2型糖尿病、血清α-HCH含量增高可能增加胆结石的患病危险,OR值及95%CI分别为5.134(1.952~13.502)、4.754(1.849~12.220)和1.357(1.094~1.854)。结论环境有机氯农药暴露可能是胆囊结石病发生的危险因素。Objective The study aimed to explore the correlation between organochlorine pesticide exposure and cholelithiasis and the risk factors for cholelithiasis amongphysical examinees atSecond Hospital in Xiamen City. Methods A total of 100 cases of initialcholelithiasis diagnosed by ultrasound were collected from health examinees at the Hospital between February and August of 2015, and health examinees without cholelithiasis were selected as the control for a 1：2 case control study. Epidemiologieal survey was conducted. A gas chromatographic electron capturing device was used to measure levels of organochlorinepesticide in peripheral blood of the subjects. Multi-factor logistic regression model analysis was used to analyze the correlation between organochlorine pesticide exposure and incidence of cholelithiasis. Results The residual level of serum a-HCH in the case group was significantly higher than that in the control group. Logistic regression analysis showed that non-alcoholic fatty liver disease, type H diabetes, and increased serum a-HCH might increase the risk of cholelithiasis; and the OR value and 95%CI were 5.134 （1.952-13.502）. 4.754 （1.849-12.220）. and 1.357 （1.094-1.854）. resneetiwlv.

关 键 词：胆囊结石 滴滴涕 六六六 有机氯农药 病例对照研究 危险因素 

分 类 号：R181.2[医药卫生—流行病学]