我院2013～2015年964例药品不良反应报告分析  

Analysis for 964 Cases Adverse Drug Reactions from 2013 to 2015 in Our Hospital

作　　者：艾冬云[1] 张锦文[2] 杨红斌[2] 丁玉峰[2] 王晨[2] 

机构地区：[1]华中科技大学同济医学院附属同济医院医院感染科,武汉430030 [2]华中科技大学同济医学院附属同济医院医院药学部,武汉430030

出　　处：《药物流行病学杂志》2017年第2期126-128,共3页Chinese Journal of Pharmacoepidemiology

摘　　要：目的:对964例药品不良反应(ADR)报告进行统计分析,提高临床用药的安全性。方法:收集2013~2015年我院ADR报告964例,从发生ADR的患者年龄、损害系统、ADR涉及的主要药品种类、严重ADR占比等进行分析。结果:964例ADR涉及的前十位药品中抗感染药有7种。主要损害系统:皮肤及其附件415例(43%)、消化系统216例(22.4%)、全身性186例(19.3%)、呼吸系统55例(5.7%)、中枢及外周神经系统44例(4.1%)、心血管系统20例(2.1%)等。其中严重ADR 38例(3.94%)。结论:医疗机构必须加强对ADR的监测力度,特别注意对出现的新的和严重的ADR的监测,保证患者安全用药。Objective：Analyze 964 reported adverse drug reactions （ADRs）, so as to improve the security of clinical drug application. Methods ：964 ADRs from 2013 to 2015 in our hospital were collected, made comprehensive analysis such as the cases age groups, impaired parts and systems, drug varieties, the proportion of severe ADR （SADR） and so on. Results：Anti-infection agents took 7 places of the top 10 drugs causing ADR. Main presentations of the ADRs were lesion of skin and its appendages （415 cases, 43% ）, damage of gastrointestinal system （216 cases, 22.4% ）, systemic lesion （19.3%）, damage of respiratory system （5.7%）, damage of central and peripheral nervous system （4.1%）, damage of cardiovascular system （2.1% ）. The proportion of SADRs （38 cases） was 3.94%. Conclusion：Medical institutions must strengthen the monitoring of ADR. Adverse reactions （ especially never occurred before） should be reported as soon as possible, to ensure the security of drug application.

关 键 词：药品不良反应 报告分析 安全用药 

分 类 号：R951[医药卫生—药学]