离子通道受其辅助亚基及外源性毒素调控的作用机制  

Regulation of ion channels by accessory subunit and peptide toxin

作　　者：郭晓奇 文明[1] 田长麟[1] 张隆华[1] GUO XiaoQi WEN Ming TIAN ChangLin ZHANG LongHua(High Magnetic Field Laboratory of Chinese Academy of Sciences, School of Life Sciences, University of Science and Technology of China, Hefei 230027, Chin)

机构地区：[1]中国科学技术大学生命科学学院,中国科学院强磁场科学中心,合肥230027

出　　处：《中国科学：生命科学》2017年第1期87-97,共11页Scientia Sinica(Vitae)

基　　金：国家自然科学基金(批准号:31100847,31670776)资助

摘　　要：离子通道是一类位于细胞膜上的跨膜蛋白,可以在电压、配体结合或机械力的作用下开放或关闭,并允许特定离子通过其跨膜孔道进出细胞.辅助亚基是一类单次跨膜或两次跨膜蛋白,可以与离子通道α亚基相互作用,改变其膜上表达量、电导特性等,同时会影响通道对药物的敏感性.动物毒素是一类含二硫键的多肽,可以选择性结合到离子通道特定位点上,产生抑制激活、延缓失活或异常开放等不同通道特性的改变.本文就近年来本实验室在离子通道受其辅助亚基及外源性毒素调控的作用机制研究方面的进展进行简要综述.The opening and closing of pore-forming ion channels are controlled by voltage, ligand, or mechanical stimulation, allowing the flow of special ions across the cellular membrane. Ion channel accessory subunits （13 subunits） normally contain one or two transmembrane helices. The 13 subunits can interact with the pore-forming subunit （a subunit） and modulate the membrane trafficking, conductance, dynamics, and drug sensitivity ofct subunits. Most animal venom toxins are peptides containing multiple disulfide bonds. Peptide toxins can bindto specific ion channels and then block or activate the conductance of these ion channels. Here, recent studies and prospects of ion channel conductance modulation by 13-subunits and/or peptide toxins are briefly summarized.

关 键 词：离子通道 辅助亚基 毒素 相互作用位点 

分 类 号：R99[医药卫生—毒理学]