革兰氏阳性病原菌表面毒力因子及其宿主识别机制  

Virulence factors on the surface of Gram-positive pathogens and mechanisms of host-pathogen recognition

作　　者：江永亮[1] 金腾川[1] 陈宇星[1] 周丛照[1] JIANG YongLiang JIN TengChuan CHEN YuXing ZHOU CongZhao(School of Life Sciences, University of Science and Technology of China, Hefei 230027, Chin)

机构地区：[1]中国科学技术大学生命科学学院,合肥230027

出　　处：《中国科学：生命科学》2017年第1期98-107,共10页Scientia Sinica(Vitae)

摘　　要：革兰氏阳性病原菌拥有多种毒力因子,它们在病原菌生长及侵染宿主的各个时期发挥着重要作用.它们不仅参与病原菌的细胞分裂和增殖,同时还介导病原菌黏附和侵染宿主.基于本研究组近十年来对两种重要的人类病原微生物肺炎链球菌和金黄色葡萄球菌的研究,并整合国内外相关研究进展,简要综述了病原菌重要表面毒力因子的结构和功能,以及与宿主天然免疫模式识别受体相互作用的分子机制.Gram-positive pathogens encode various virulence factors, which are required for their growth and pathogenesis. These virulence factors not only participate in cell division and proliferation, but also mediate adhesion to and invasion of the host. Owing to investigations on the two important human pathogens Streptococcus pneumoniae and Staphylococcus aureus in the last decade, we have obtained some meaningful insights into the virulence factors on the bacterial surface. Here, we focus on the structures and functions of several major virulence factors in order to elucidate the molecular mechanism by which they contribute to pathogen-host recognition.

关 键 词：病原菌 毒力因子 结构与功能 天然免疫 宿主识别 

分 类 号：R378[医药卫生—病原生物学]