酸枣仁汤治疗更年期失眠患者的疗效分析  

Efficacy observation of semen ziziphi spinosae decoction on climacteric insomnia

作　　者：赵国鹏[1] 张红丽[1] 薛晨[2] 冯五金[2] 

机构地区：[1]山西中医学院 [2]山西省中医药研究院

出　　处：《山西中医》2017年第2期20-21,31,共3页Shanxi Journal of Traditional Chinese Medicine

摘　　要：目的:对更年期失眠患者给予酸枣仁汤治疗,观察其对患者PSQI睡眠指标的影响。方法:选取到我院就诊的更年期失眠患者120例,按随机数字表法,随机分为两组。对照组给予阿普唑仑治疗,观察组给予酸枣仁汤加减治疗;以患者PSQI睡眠指标为观察指标,评价两组治疗方法的利弊。结果:观察组总有效率为91.94%(95%CI=85.16%~98.72%),对照组为84.48%(95%CI=75.16%~93.80%),两组综合疗效比较(u=1.958 9,P=0.050 1),处于临界状态;与对照组比较,观察组PSQI量表睡眠质量、入睡时间、睡眠障碍、催眠药物、日间功能障碍、总分评分参数明显降低(P<0.01);不良反应也低于对照组。结论:采用酸枣仁汤治疗更年期失眠患者的疗效优于阿普唑仑,其收益为,OR=0.48(95%CI=0.15~1.52),NNT=13(95%CI=5.28~38.22)。Objective： To treat the patients with climacteric insomnia with semen ziziphi spinosae decoction,and to observe the effect of semen ziziphi spinosae decoction on Pittsburgh sleep quality index（ PSQI） of patients.Methods： 120 cases of patients with climacteric insomnia selected and treated in our hospital were divided randomly into two groups. The control group were treated with alprazolam,while the observation group was treated with modified semen ziziphi spinosae decoction. Patients＇ PSQI was taken as observation index,and the advantages and disadvantages of two treatments were evaluated in two groups. Results： The total effective rate of observation group was 91. 94%（ 95% CI = 85. 16%- 98. 72%）,while the total effective rate of control group was 84. 48%（ 95%CI = 75. 16%- 93. 80%）. Compared the comprehensive efficacy in two groups（ u = 1. 958 9,P = 0. 050 1）,the difference is in critical state. Compared with control group,in observation group,PSQI scale,sleep quality,time of falling asleep,sleep disorder,hypnotic drugs,daytime dysfunction and total score parameters were significantly reduced（ P〈0. 01）; the adverse reactions were also lower than in control group. Conclusion： The effect of semen ziziphi spinosae decoction on climacteric insomnia is better than that of alprazolam,its benefit is OR = 0. 48（ 95%CI = 0. 15- 1. 52） and NNT = 13（ 95% CI = 5. 28- 38. 22）.

关 键 词：失眠 更年期 酸枣仁汤 临床观察 

分 类 号：R256.23[医药卫生—中医内科学]