健脾补肾泄浊活血方配合别嘌醇治疗痛风肾疗效观察  

Efficacy observation of jianpibushen xiezhuohuoxue formula with Allopurinol on gouty nephropathy

作　　者：周卫国[1] 胡彦兴[1] 卓彩琴[1] 

机构地区：[1]福建省永安市三明第二医院(福建中医药大学第五临床医学院)

出　　处：《山西中医》2017年第2期24-26,共3页Shanxi Journal of Traditional Chinese Medicine

摘　　要：目的:观察健脾补肾泄浊活血方配合别嘌醇对脾肾不足,湿浊瘀阻型痛风肾患者的疗效。方法:将病、证符合入选要求的52例患者随机分为对照及治疗组,前者予别嘌醇口服,后者在对照组基础上增自拟中药方,两组一般治疗一致,疗程12周。记录并分析两组尿素氮(BUN)、肌酐(Cr)、血尿酸(BUA)、24 h尿蛋白检验客观指标等。结果:治疗组总有效率为92.31%(95%CI=74.90%~99.10%),对照组为76.92%(95%CI=60.72%~93.12%),两组综合疗效比较(u=2.068 3,P=0.038 7),差异有显著性意义;与对照组比较,治疗组可显著降低BUN、Cr、BUA、24h尿蛋白参数。结论:采用别嘌醇治疗的基础上应用健脾补肾泄浊活血方治疗脾肾不足、湿浊瘀阻型痛风肾患者的疗效优于单纯应用别嘌醇治疗,其收益为OR=0.28(95%CI=0.05~1.53),NNT=7(95%CI=2.86~30.19)。OR的95%CI跨过1,可能与该观察病例数不足有关。Objective： to observe the effect of jianpibushen xiezhuohuoxue formula combined with Allopurinol on gouty nephropathy of pleen and kidney deficiency and turbid damp and blood- stasis obstruction. Methods： 52 cases of patients whose disease and syndrome met the selected requirements were divided randomly into control group and treatment group. The control group was treated with oral Allopurinol,while the treatment group was treated plus with self-made TCM formula on the basis of control group. Both groups were treated synchronously for 12 weeks.Blood urea nitrogen（ BUN）,creatinine（ Cr）,blood uric acid（ BUA） and 24h-urinary protein were recorded and analyzed in two groups,in order to check the objective indexes. Results： The total effective rate of treatment group was 92. 31%（ 95% CI = 74. 90%- 99. 10%）,while the control group was 76. 92%（ 95% CI = 60. 72%-93. 12%）. Compared the comprehensive efficacy in two groups（ u = 2. 068 3,P = 0. 038 7）,the difference was statistically significant. Compared with the control group,the treatment group can significantly reduce the parameters of BUN,Cr,BUA and 24 h urinary protein. Conclusion： The effect of jianpibushen xiezhuohuoxue formula combined with Allopurinol on gouty nephropathy of pleen and kidney deficiency and turbid damp and blood- stasis obstruction is better than that of pure Allopurinol,its benefit is OR = 0. 28（ 95% CI = 0. 05- 1. 53） and NNT = 7（ 95% CI = 2. 86- 30. 19）. 95% CI of OR is across 1,which may be related to the insufficient number of observed cases.

关 键 词：痛风肾 脾肾不足 湿浊瘀阻 中西医结合疗法 

分 类 号：R589.7[医药卫生—内分泌]