穿心莲内酯滴丸联合丹溪玉屏风颗粒对变应性鼻炎患儿免疫功能的影响  

Effects of Andrographolide Driping Pills Combined with Danxi Yupingfeng Granules on Immunologic Function of Children with Allergic Rhinitis

作　　者：贺莉[1] 曹建英[1] 侯明滨[1] 

机构地区：[1]潍坊市妇幼保健院,山东潍坊261011

出　　处：《中国药房》2017年第5期643-645,共3页China Pharmacy

基　　金：潍坊市中医药科研立项项目[No.2015年(第四类)第031号]

摘　　要：目的:探讨穿心莲内酯滴丸联合玉丹溪屏风颗粒对变应性鼻炎(AR)患儿免疫功能的改善作用。方法:将208例AR患儿按随机数字表法分为对照组、观察Ⅰ组、观察Ⅱ组、观察Ⅲ组,各52例。对照组患儿口服氯雷他定糖浆10 mL,qd;观察Ⅰ组患儿给予丹溪玉屏风颗粒15 g,bid+穿心莲内酯滴丸0.6g,tid;观察Ⅱ组患儿给予等剂量穿心莲内酯滴丸治疗;观察Ⅲ组患儿给予等剂量丹溪玉屏风颗粒治疗。4组患儿均治疗2周,2周后若复发则口服氯雷他定糖浆缓解症状。比较治疗前,治疗后1、2周及治疗结束后3个月4组患儿的血清总免疫球蛋白(Ig)E及辅助T淋巴细胞1(Th1)/辅助T淋巴细胞2(Th2)水平,观察治疗结束后3个月因AR复发临时口服氯雷他定糖浆的患儿。结果:治疗前,4组患儿血清总IgE及Th1/Th2水平比较,差异无统计学意义(P>0.05);治疗后1周时,4组患儿血清总IgE及Th1/Th2水平显著改善,差异有统计学意义(P<0.05),但组间比较差异无统计学意义(P>0.05);治疗后2周,4组患儿血清总IgE及Th1/Th2水平均显著改善,且观察组显著优于对照组,差异有统计学意义(P<0.05);治疗结束后3个月,观察组患儿血清总IgE及Th1/Th2水平均显著改善,且优于对照组,差异均有统计学意义(P<0.05),对照组患儿与治疗前比较差异无统计学意义(P>0.05)。观察Ⅰ组患儿复发率显著低于观察Ⅱ、观察Ⅲ及对照组,差异有统计学意义(P<0.05)。4组患儿均未见明显不良反应发生。结论:穿心莲内酯滴丸联合丹溪玉屏风颗粒能显著改善AR患儿免疫功能、降低复发率,且安全性高。OBJECTIVE：To investigate the improvement effects of andrographolide dripping pills combined with Danxi yupingfeng granules on inmiunologic function of children with allergic rhinitis（AR）.METHODS：Two hundred and eight AR children were randomly divided into control group,observation group Ⅰ,observation group Ⅱ,observation group Ⅲ,with 52 cases in each group.Control group was given Loratadine syrup 10 mL,qd;observation group Ⅰ was given Danxi yupingfeng granules 15 g,bid＋Andrographolide dripping pills 0.6 g,tid;observation group Ⅱ was given constant dose of Andrographolide dripping pills;observation group Ⅲ was given constant dose of Danxi yupingfeng granules.Four groups were treated for 2 weeks.2 weeks later,they were given Loratadine syrup orally if the symptom appeared again.The levels of IgE and Th1/Th2 were compared among 4 groups before treatment,1,2 weeks after treatment,3 months after the end of treatment.The children receiving Loratadine syrup orally due to the recurrence of AR 3 months after the end of treatment were observed.RESULTS：Before treatment,there was no statistical significance in serum levels of IgE and Th1/Th2 among groups（P〉0.05）.One week after treatment,serum levels of IgE and Th1/Th2 were improved significantly,with statistical significance（P〈0.05）;but there was no statistical significance among 4 groups（P〉0.05）.Two weeks after treatment,serum levels of IgE and Th1/Th2 were improved significantly,and the observation groups were significantly better than the control group,with statistical significance（P〈0.05）.Three months afterthe end of treatment,serum levels of IgE and Th1/Th2 in observation group were improved significantly and better than control group,with statistical significance（P〈0.05）;there was no statistical significance in control group,compared to before treatment（P〉0.05）.The recurrence rate of observation group Ⅰ was significantly lower than that of observation group Ⅱ,observation group Ⅲ and control group,with sta

关 键 词：穿心莲内酯滴丸 丹溪玉屏风颗粒 变应性鼻炎 免疫功能 

分 类 号：R969[医药卫生—药理学]