腰痛静息态功能磁共振比率低频振幅的研究  

Altered fractional amplitude of low frequency fluctuation in experimental low back pain: a resting-state fMRI

作　　者：张珊珊[1,2] 吴文[2] 王楚怀[1] 杨建明[3] 

机构地区：[1]中山大学附属第一医院康复医学科,广州510800 [2]南方医科大学珠江医院康复医学科 [3]南方医科大学珠江医院影像诊断科

出　　处：《中国康复医学杂志》2017年第2期140-145,共6页Chinese Journal of Rehabilitation Medicine

基　　金：国家自然科学基金项目(81473769);广东省自然科学基金项目(2014A030313335)

摘　　要：目的:采用功能磁共振成像(fMRI)技术和比率低频振幅(fALFF)方法探讨静息状态下腰痛脑功能变化的特点。方法:采用3.0T磁共振成像仪采集12例健康志愿者(7男5女,23.8±3.6岁)正常状态与腰痛状态(肌肉注射5%高渗盐水)的静息态fMRI数据。采用DPARSF软件对所得数据进行预处理和fALFF分析、SPM8进行配对t检验比较两种状态下脑比率低频振幅的差异,并将疼痛状态的图像与疼痛强度VAS评分作相关性分析。结果:与正常状态相比,腰痛fALFF值增高的脑区包括双侧额下回、双侧小脑扁桃体、右海马旁回,fALFF值降低的脑区包括右额上回、右后扣带回、左初级躯体感觉皮质(S1)、双侧枕叶(P<0.001,体素K≥10)。腰痛状态右额下回fALFF值与VAS评分呈正相关,左S1、左枕叶fALFF值与VAS评分呈负相关(P<0.005,K≥10)。结论:静息状态下腰痛受试者部分脑区存在脑功能活动异常,这可能与疼痛刺激引起认知、情绪功能改变有关。Objective： To explore the characteristics of the fractional amplitude of low frequency fluctuation（fALFF） in experimental low back pain using resting-state functional magnetic resonance imaging（fMRI）.Method： Twelve healthy subjects（male： 7, female： 5; age： 23.8±3.6 years） were separately performed restingstate fMRI 3.0T scans at no-pain（baseline） and pain of the back muscle（intramuscular injection of 5% hypertonic saline） situation. The fMRI datas were analyzed with paired t-test to compare fALFF changes of the brain between baseline and pain status by DPARSF, and SPM8. Correlation analysis was performed between the fALFF images during low back pain and pain intensity（visual analogue scale, VAS）.Result： Subjects with low back pain showed significantly increased fALFF in bilateral inferior frontal gyrus, bilateral cerebellum posterior lobe-cerebellar tonsil, right parahippocampal gyrus, and decreased fALFF in the right superior frontal gyrus, right posterior cingulate gyrus（PCC）, left primary somatosensory cortex（S1）, bilateral occipital gyrus（P〈0.001, cluster threshold≥10）. Visual analogue scale positively correlated with fALFF value in the right inferior frontal gyrus, but negatively correlated with fALFF value in the left S1 and occipital gyrus（P〈0.005, cluster threshold≥10）.Conclusion： The findings reveal that there are abnormal spontaneous resting-state activities in some brain regions in experimental low back pain, and propose that is disruptions of the cognition and emotion during pain stimulation.

关 键 词：腰痛 静息态 功能磁共振成像 比率低频振幅 

分 类 号：R681.5[医药卫生—骨科学]