大补阴丸对去卵巢所致骨质疏松症大鼠骨组织形态计量学指标的影响  

The Effect of DaBuYinWan on the Bone Histomorphology of Ovariectomized Rats Pilon

作　　者：汪文来[1] 刘梅洁[1] 于峥[1] 李艳[1] 王少君[1] 刘红[1] 潘静华[1] 王震[1] 赵红霞[1] 

机构地区：[1]中国中医科学院中医基础理论研究所,北京100700

出　　处：《中国中医基础医学杂志》2017年第1期78-79,共2页JOURNAL OF BASIC CHINESE MEDICINE

摘　　要：目的:观察大补阴丸对去卵巢所致骨质疏松症大鼠胫骨骨组织形态计量学指标的影响,以探讨其对骨质疏松症的作用。方法:将88只雌性Wistar大鼠按随机数字表法分为空白对照组、假手术组、模型组、己烯雌酚组和大补阴丸高、中、低剂量组7组。采用摘除卵巢的方法制作骨质疏松症动物模型,在灌胃给药3个月后,运用骨组织形态计量学方法对大鼠胫骨不脱钙骨切片进行形态计量。结果:与模型组比较,大补阴丸高、中剂量组TBV%显著增高,TRS%、TFS%、MAR、m AR显著降低。结论:大补阴丸对去卵巢所致的大鼠骨质疏松症具有一定的治疗作用。Objective： Observe the influence of DaBuYinWan on the bone histomorphology of ovariectomized rats pilon,in order to investigate the effect of DaBuYinWan on Osteoporosis. Methods： The 88 female rats were randomly divided into 7 groups , concluding normal group, sham operation group,model group, positive group and Dabuyinwan（ high, middle,low-dose） group. Establish a rat osteoporosis model with removing the ovaries. After three months administration, measure the undecalcified sections in bone by bone histomorphometry. Results： Compared with the model group, TBV% in positive group and Dabuyinwan（high,middle-dose） group increased obviously, TRS% , TFS% , MAR and mAR decreased obviously.

关 键 词：大补阴丸 骨质疏松症 骨组织形态计量学 

分 类 号：R285.5[医药卫生—中药学]