血清TPS水平对乳腺癌诊断价值的荟萃分析  

Diagnostic value of serum TPS level on breast carcinoma: a meta-analysis

作　　者：王竹[1,2] 王前前[2] 刘明华 

机构地区：[1]西南医科大学,泸州646000 [2]四川大学华西医院肿瘤分子诊断研究室,成都610041

出　　处：《中国抗生素杂志》2017年第2期I0004-I0008,共5页Chinese Journal of Antibiotics

基　　金：国家自然科学基金(No.81172176)

摘　　要：目的本研究旨在探讨血清组织多肽特异性抗原(TPS)对乳腺癌的诊断效能。方法通过计算机检索CNKI、维普及Pub Med数据库,收集有关血清TPS诊断乳腺癌的诊断试验,并按纳入与排除标准筛选文献并提取数据,采用Meta Disc1.4软件进行Meta分析。结果共19篇文献符合纳入标准入组本系统评价,样本量为3060例,其中经病理学诊断为乳腺癌患者1506例,正常或乳腺良性疾病对照组1554例。Meta分析结果显示:TPS水平诊断乳腺癌的总灵敏度、特异度及诊断优势比分别为:0.59(95%CI:0.56~0.61)、0.88(95%CI:0.86~0.89)和11.86(95%CI:6.99~20.14);SROC曲线下面积(AUC)为0.8686,Q指数为0.7991。结论用TPS单独诊断乳腺癌效能较低,应结合临床表现及其他肿瘤标志物检验结果进行综合分析。Objective The aim of the present study was to establish the overall diagnostic accuracy of the measurements of serum tissue polypeptide-specific antigen（TPS） for breast carcinoma. Methods The databases of CNKI, VIP and PubMed were used to search all the relevant texts which were about the diagnostic values of TPS in the breast carcinoma. The data about the accuracy of the included studies were extracted and analyzed using MetaDisc 1.4 software. Results Twenty studies were collected. The sample size was 3060 cases, of which 1506 cases confirmed pathologically were breast carcinoma, and 1554 controls. The results of meta-analysis showed that： Pooled sensitivity, specificity and diagnostic odds ratio（DOR） were 0.59（95%CI： 0.56-0.61）, 0.88（95%Ch 0.86-0.89） and 11.86（95%CI： 6.99-20.14）respectively. The area under ROC curve （AUC） and Q index were 0.8686 and 0.7991. Conclusion The current evidence does not recommend using TPS alone for the diagnosis of breast carcinoma. The results of tumor marker assays should be interpreted in parallel with clinical findings and the results of other tumor markers＇ tests.

关 键 词：TPS 乳腺癌 诊断效能 META分析 

分 类 号：R979.1[医药卫生—药品]