大鼠肝纤维化磁共振扩散加权成像表观弥散系数与病理对照研究  

Research of the ADC Value of Hepatic Fibrosis in Magnetic Resonance DWI in Rats with Different Pathological Stagings

作　　者：王启苑[1] 张维[2] 范国华[3] WANG Qi-yuan ZHANG Wei FAN Guo-hua(Department of Radiology, Second Affiliated Hospital of Zhejiang University, Hangzhou, Zhejiang, 310009, China)

机构地区：[1]浙江大学附属第二医院放射科,浙江杭州310009 [2]南京市儿童医院放射科,江苏南京210008 [3]苏州大学附属第二医院影像科,江苏苏州215004

出　　处：《中国血液流变学杂志》2016年第2期160-163,229,共5页Chinese Journal of Hemorheology

基　　金：江苏省苏州市科技发展计划（应用基础研究）基金资助项目（SYS201474）

摘　　要：目的探讨磁共振扩散加权成像（DWI）．对大鼠肝纤维化早期诊断及其分期的价值。方法CCl4法建立大鼠肝纤维化实验组，并行DWI检查，根据肝纤维化病理分期进行组间表观弥散系数（ADC）的比较。结果（1）随着肝纤维化病理分期的增加，DWI信号强度呈增加趋势，而ADC值逐渐减小。（2）b值为600s／mm^2和800s／mm^2时，对照组与实验组组间ADC值比较差异均有统计学意义（F=10．422，P〈0．001；F=16．637，P〈0．001）；ADC值与肝纤维化分期呈负相关性（r=0．628，P〈O．001）。结论磁共振DWI的ADC值对肝纤维化早期诊断具有较高的价值，并具有较好的相关性；梯度因子b=800s／mm^2时ADC值对肝纤维化的分期更敏感。Objective To investigate the value of DWI in early diagnosis and staging of rats hepatic fibrosis. Methods The model of hepatic fibrosis by CCI4 was established on rats. DWI was performed in all rats and the ADC value was compared between rats of different pathological stagings. Results （1）As the pathological staging of hepatic fibrosis increases, the intensity of DWI rises while the ADC value declines. （2）The differences of ADC values among subgroups of different pathological stagings were statistically significant when b value was 600 s/ mm^2 （F=10.422, P 〈 0.001） or 800 s/mm^2 （F=16.637, P 〈 0.001）. The ADC value was negatively correlated with pathological staging of hepatic fibrosis （r=-0.628, P 〈 0.001）. Conclusion Hepatic fibrosis could be staged based on the value of ADC with good correlation when b value was 600 s/mm^2 or 800 s/mm^2, in which ADC was more sensitive to pathological staging of hepatic fibrosis when b was 800 s/mm^2 compared to 600 s/mm^2.

关 键 词：肝纤维化 大鼠 磁共振成像 扩散加权成像 

分 类 号：R445.2[医药卫生—影像医学与核医学]