老年慢性心力衰竭患者甲状腺激素和同型半胱氨酸水平与心功能关系的研究  

The Relationship Between Thyroid Hormone, Homocysteine Levels and Heart Function in Elderly Chronic Heart Failure

作　　者：王婷婷 李辉[2] 范建国 范婷婷 WANG Ting-ting LI Hui FAN Jian-guo FAN Ting-ting(Nanjing Qilin Community Healthy Service Centre, Nanjing, Jiangsu, 21113 5, China)

机构地区：[1]南京市麒麟社区卫生服务中心,江苏南京211135 [2]南京医科大学第一附属医院检验科,江苏南京210029 [3]南京艾迪康临床医学检测中心,江苏南京211103

出　　处：《中国血液流变学杂志》2016年第2期227-229,共3页Chinese Journal of Hemorheology

摘　　要：目的探讨老年慢性心力衰竭（chronic heart failure，CHF）患者甲状腺激素（thyroid hormone，TH）和同型半胱氨酸（homocysteine，HCY）水平与心功能的关系。方法化学发光免疫分析测定156例CHF患者（心功能Ⅱ级39例，Ⅲ级78例和Ⅳ级39例）和60名对照组血清TH（T3，T4和TSH）和HCY水平以及心功能左室射血分数（1eft ventricular ejection fraction，LVEF）和左室舒张末期内径（left ventricular end-diastolic dimension，LVEDd）并进行对比性分析。结果CHF患者TH水平随心功能Ⅱ～Ⅳ级的严重程度的增加，血清T3和T4水平明显降低，血清TSH水平稍增高，而血清HCY水平明显增高。结论血清TH和HCY水平是早期诊断和衡量老年CHF严重程度的有价值指标。Objective To explore the relationship between TH, HCY and heart function in elderly chronic heart failure （CHF）. Methods The serum TH （including T3, T4 and TSH） and HCY levels were determined in 156 patients with CHF （39 cases NYHA Ⅱ, 78 cases NYHA Ⅲ and 39 cases NYHA Ⅳ） and 60 controls, but the heart functions （ LVEF and LVEDd ） were determined also with compared analysis. Results The serum T3 and T4 levels were lower, TSH was a little higher and HCY was obviously higher in patients with elderly CHF （NYHA Ⅱ ～ NYHA Ⅳ）. Conclusion The serum TH and HCY levels were valuable indexes for elderly CHF early diagnosis and severity analysis.

关 键 词：慢性心力衰竭 甲状腺激素 同型半胱氨酸 心功能 

分 类 号：R446.1[医药卫生—诊断学] R541.61[医药卫生—临床医学]