西地那非对西藏小型猪慢性肺动脉高压模型体循环压力的影响  

Effects of sildenafil on systemic blood pressure in Tibet minipigs with chronic pulmonary hypertension

作　　者：侯梦[1,2] 刘蓉[1,2] 廖海星[1] 汪延生[1,2] 岳敏[3] 张新凤[1] 吴清洪[3] 李洪涛[1,2] 顾为望[3] HOU Meng LIU Rong LIAO Haixing WANG Yansheng YUE Min ZHANG Xinfeng WU Qinghong LI Hongtao GU Weiwang(Guangzhou Institute of Respiratory Diseases, the Affiliated First Hospital, Guangzhou Medical University, Guangzhou 510120 The State Key Laboratory of Respiratory Diseases, Guangzhou 510230 Labora- tory Animal Centre, Southern Medical University, Guangzhou 510515)

机构地区：[1]广州医科大学附属第一医院广州呼吸疾病研究所,广州510120 [2]呼吸疾病国家重点实验室,广州510230 [3]南方医科大学实验动物中心,广州510515

出　　处：《郑州大学学报（医学版）》2016年第5期610-613,共4页Journal of Zhengzhou University(Medical Sciences)

基　　金：广东省科研基础条件建设项目 2012B060300032

摘　　要：目的:观察西地那非对西藏小型猪慢性肺动脉高压(PH)模型体循环压力的影响。方法:18头2月龄西藏小型猪随机分为正常对照组、模型组和治疗组,每组6头。模型组和治疗组小型猪腹腔注射野百合碱42 d用以制备PH模型,正常对照组给予相同剂量溶剂。第42天,超声心动图扫查估算肺动脉压。第43天开始,治疗组喂食西地那非(6.0 mg·kg-1·d-1),共21 d。第64天超声心动图扫查估算动物肺动脉压,左颈动脉插管测定体循环压力。结果:与对照组比较,模型组肺动脉压和体循环压力均明显升高(P<0.05);与模型组相比,治疗组肺动脉压均降低,同时体循环压力亦明显下降,甚至低于正常对照组(P<0.05)。结论:西地那非在降低肺动脉压的同时也降低体循环压力。Aim： To investigate the effects of sildenafil on the systemic blood pressure of Tibet minipig models with chronic pulmonary hypertension（PH）.Methods： A total of 18 Tibet minipigs were randomly allocated into control group, model group and treatment group, 6 in each group. The Tibet minipigs in model group and treatment group were treated with monocrotaline（MCT）for 42 d to establish PH model.Since day 43, the treatment group was treated with sidenafil（6.0 mg·kg-1·d-1）for 3 weeks. Conventional transthoracic echocardiography was performed at day 42 and day 64.The systemic blood pressure was measured by left carotid artery cannulation linked to a MedLab biological signal collecting and processing system at day 64.Results： At day 64, pulmonary artery pressure and systemic blood pressure of the model group were higher than those of control group（P〈0.05）; pulmonary artery pressure and systemic blood pressure of the treatment group were lower than those of the model group（P〈0.05）, and systemic blood pressure was even lower than that of control group（P〈0.05）.Conclusion： Sildenafil could reduce pulmonary artery pressure, at the same time, also reduce systemic pressure.

关 键 词：西地那非 肺动脉高压 西藏小型猪 体循环血压 

分 类 号：R543.2[医药卫生—心血管疾病]